Jonathan Mill | The Medical School | University of Exeter

Professor Jonathan Mill

HoD - Clinical and Biomedical Sciences, Professor of Epigenomics

J.Mill@exeter.ac.uk

01392 408301

RILD Building Level 3 [South]

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Jonathan is Professor of Epigenomics at the University of Exeter Medical School where he heads the Complex Disease Epigenomics Group. He graduated with a degree in Human Sciences from Oxford University, where he took a particular interest in cannibalism, before undertaking his PhD in psychiatric genetics at the Social, Genetic & Developmental Psychiatry Research Centre at the Institute of Psychiatry, King's College London. After spending three years as a Canadian Institutes of Health Research (CIHR) postdoctoral fellow at the University of Toronto, he returned to the Institute of Psychiatry to establish the Psychiatric Epigenetics group. He was appointed as Professor of Epigenomics at the University of Exeter in September 2012.

His group takes an integrated genomics approach to complex disease, with a particular focus on diseases affecting the central nervous system. His team is currently studying the causes and consequences of molecular variation in the brain and the rtole this plays in both neurodegenerative disease (e.g. Alzheimer's disease, ALS, and other types of dementia) and neurodevelopmental disorders (e.g. autism, and schizophrenia). His group was funded as part of the NIH Epigenomics Roadmap Initiative, representing the only award made under this scheme outside of North America and putting them at the forefront of complex disease epigenomic research. They are also the only UK group involved in the PsychENCODE consortium, profiling epigenomic variation in autism brain and across neurodevelopment.

Jonathan has received numerous international awards and prizes. These include both a Young and Distinguished Investigator Award from the Brain & Behavior Research Foundation, an Advanced Investigator Award from the American Asthma Foundation, the British Medical Association’s Margaret Temple Award, and the ISPG Theodore Reich Prize from the International Society of Psychiatric Genetics. Jonathan is an ISI Web of Science “Highly-Cited Researcher”, ranking in the top 1% of researchers by citations for field and year. He is a member of the Medical Research Council (MRC) Neuroscience and Mental Health Board, and sits on grant advory boards for Autistica and the Alzheimer's Society.

Qualifications

PhD Psychiatric Genetics (Institute of Psychiatry, King’s College London)
BA Human Sciences (Oxford University)

Career

Previous positions

2013-2017 Professor Institute of Psychiatry, KCL

2009-2013 Senior Lecturer Institute of Psychiatry, KCL

2007-2009 Lecturer Institute of Psychiatry, KCL

2005-2007 CIHR Fellow University of Toronto, Canada

Research group links

Research

Research interests

Sequencing the genome was only the first step in our quest to understand how genes are expressed and regulated. Sitting above the DNA sequence is a second layer of information (the 'epigenome') that regulates several genomic functions, including when and where genes are turned-on or -off. 'Epigenetics' refers to the reversible regulation of gene expression mediated principally through changes in DNA methylation and chromatin structure. Epigenetic processes are essential for normal cellular development and differentiation, and allow the regulation of gene function through non-mutagenic mechanisms. Unlike the DNA sequence, which is stable and strongly conserved, epigenetic processes can be tissue-specific, developmentally-regulated and dynamic. For example, mounting evidence suggests that epigenetic processes can be influenced by exposure to factors in the environment.

Key areas of research

The work in my group is focussed on understanding the causes and consequences of molecular variation in the human brain, and its relevance to neuropsychiatric phenotypes. We take an integrated genomics approach and have considerable experience in cutting-edge genomic profiling methods and bioinformatics. We are pioneering systems biology approaches to study the molecular pathology of neurodevelopmental and neurodegenerative disorders and have made considerable progress in four key areas of research:

1. Mapping gene regulation in the human brain

We have led advances in understanding how epigenomic variation influences gene regulation in the human brain, profiling DNA and histone modifications across specific brain regions and cell-types and relating these to neuropsychiatric and neurodegenerative disease. This work - supported by the NIH Epigenomics Roadmap Initiative, the PsychENCODE Consortium, the Simons Foundation (SFARI) and the UK Medical Research Council (MRC) - has resulted in a systematic analysis of epigenomic processes in the human brain. We are particularly interested in mapping gene regulation in the developing human brain at a single-cell level. These studies have confirmed the prenatal period as a time of considerable epigenomic and transcriptional plasticity and highlighted dynamic patterns of gene regulation in genes implicated in neurodevelopmental phenotypes including schizophrenia. Finally, we are utilizing novel long-read sequencing approaches to map alternative splicing and isoform diversity in the human brain.

Leung SK, Jeffries AR, Castanho I, Jordan BT, Moore K, Davies JP, Dempster EL, Bray NJ, O'Neill P, Tseng E, Ahmed Z, Collier DA, Jeffery ED, Prabhakar S, Schalkwyk L, Jops C, Gandal MJ, Sheynkman GM, Hannon E, Mill J. Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing. Cell Rep. 2021 Nov 16;37(7):110022.
Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G, O'Donovan MC, Schalkwyk LC, Bray NJ, Mill J. Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nat Neurosci. 2016 Jan;19(1):48-54.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, Mill J. Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol. 2016 Feb 16;17(1):27.
Spiers H, Hannon E, Schalkwyk L, Smith R, Wong C, O’Donovan M, Bray N, Mill J. Methylomic trajectories across human fetal brain development. Genome Research. 2015 Mar;25(3):338-52.
Davies M, Volta M, Pidsley P, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, Al-Sarraj S, Dobson R, Schalkwyk L, Mill J. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biology. 13(6):R43.

2. Profiling the epigenome in health and disease.

We have coordinated the first systematic analyses of epigenetic variation in the brain associated with schizophrenia, autism and Alzheimer’s disease, and are currently funded to perform large-scale studies in specific neural cell-types. Our work in this area has had considerable impact. As part of the PsychENCODE consortium, for example, we have recently assessed epigenetic and transcriptional differences in autism brain, highlighting a convergent molecular pathology enriched for genes involved in neurodevelopmental processes. Finally we are investigating transcriptional and regulatory genomic alterations in rodent and cellular models of human brain disease. For example, we find widespread changes associated with neuropathology in transgenic rodent models of Alzheimer’s disease, with striking overlap with the genes/pathways identified in our analyses of human post-mortem brain tissue.

Marzi S, Ribarska T, Smith A, Hannon E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, Beck S, Newman S, Lunnon K, Schalkwyk L, Mill J. A histone acetylome-wide association study of Alzheimer's disease: neuropathology-associated regulatory variation in the human entorhinal cortex. Nat Neurosci. 2018 Nov;21(11):1618-1627.
Hannon E, Dempster E, Viana J, Burrage J, Smith AR, Macdonald R, St Clair D, Mustard C, Breen G, Therman S, Kaprio J, Toulopoulou T, Hulshoff Pol HE, Bohlken MM, Kahn RS, Nenadic I, Hultman CM, Murray RM, Collier DA, Bass N, Gurling H, McQuillin A, Schalkwyk L, Mill J. An integrated genetic-epigenetic analysis of schizophrenia: Evidence for co-localization of genetic associations and differential DNA methylation. Genome Biology. 2016 17(1):176.
Pidsley R, Viana J, Hannon E, Spiers HH, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk LC, Bray NJ, Mill J. Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. Genome Biol. 2014 Oct 28;15(10):483.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, Condliffe D, Harries LW, Katsel P, Haroutunian V, Kaminsky Z, Joachim C, Powell J, Lovestone S, Bennett DA, Schalkwyk LC, Mill J. Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci. 2014 Sep;17(9):1164-70.
Viana J, Hannon E, Dempster E, Pidsley R, Spiers H, Troakes C, Turecki G, Schalkwyk LC, Mill J. Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions. Human Molecular Genetics. 2017 26(1):210-225.
Hannon E, Dempster EL, Mansell G, Burrage J, Bass N, Bohlken MM, Corvin A, Curtis CJ, Dempster D, Di Forti M, Dinan TG, Donohoe G, Gaughran F, Gill M, Gillespie A, Gunasinghe C, Hulshoff HE, Hultman CM, Johansson V, Kahn RS, Kaprio J, Kenis G, Kowalec K, MacCabe J, McDonald C, McQuillin A, Morris DW, Murphy KC, Mustard CJ, Nenadic I, O'Donovan MC, Quattrone D, Richards AL, Rutten BP, St Clair D, Therman S, Toulopoulou T, Van Os J, Waddington JL, Sullivan P, Vassos E, Breen G, Collier DA, Murray RM, Schalkwyk LS, Mill J. DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia. Elife. 2021 Feb 26;10:e58430. doi: 10.7554/eLife.58430.
Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, Moore K, O'Neill P, Lunnon K, Collier DA, Ahmed Z, O'Neill MJ, Mill J. (2020). Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell Reports, 30(6), 2040-2054.e5. doi:10.1016/j.celrep.2020.01.063

3. Exploring genetic and stochastic allelic variation in gene regulation in the central nervous system.

My team has undertaken systematic analyses of how genetic variation influences transcriptional and regulatory mechanisms in the human brain. Our recent work, for example, has shown that cis-acting genetic influences on DNA methylation are widespread in the developing and mature central nervous system. We have highlighted how DNA methylation quantitative trait loci (mQTLs) in the brain are enriched in genomic regions associated with neurodevelopmental phenotypes including schizophrenia. We have used these datasets to refine and fine-map genomic regions associated with disease, using approaches such as Bayesian colcalization and Summary data-based Mendelian Randomization (SMR). I co-lead the Genetics of DNA Methylation Consortium that has recently generated the largest analysis of mQTLs in >30,000 individuals. We are also investigating stochastic patterns of gene regulation in the brain, highlighting how clonal level random allelic expression imbalance and random monoallelic expression provides cellular heterogeneity within the developing central nervous system by modulating allelic dosage.

Hannon E, Gorrie-Stone TJ, Smart MC, Burrage J, Hughes A, Bao Y, Kumari M, Schalkwyk LC, Mill J. Leveraging DNA-Methylation Quantitative-Trait Loci to Characterize the Relationship between Methylomic Variation, Gene Expression, and Complex Traits. Am J Hum Genet. 2018 103(5):654-665.
Hannon E, Weedon M, Bray N, O'Donovan M, Mill J. Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci. Am J Hum Genet. 2017 Jun 1;100(6):954-959.
Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G, O'Donovan MC, Schalkwyk LC, Bray NJ, Mill J. Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nat Neurosci. 2016 Jan;19(1):48-54.
Jeffries AR, Uwanogho DA, Graham C, Perfect LW, Dempster E, Mill J*, Price J*. Erasure and Re-establishment of Random Monoallelic Expression after epigenetic reprogramming and lineage commitment. RNA. 2016 Oct;22(10):1620-30.
Schalkwyk LC, Meaburn EL, Smith R, Dempster EL, Jeffries AR, Davies MN, Plomin R, Mill J. Allelic skewing of DNA methylation is widespread across the genome. American Journal of Human Genetics. 2010 Feb 12;86(2):196-212.
Genetics of DNA Methylation Consortium. Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nature Genetics. Nat Genet. 2021 Sep;53(9):1311-1321. doi: 10.1038/s41588-021-00923-x. Epub 2021 Sep 6.PMID: 34493871

4. Theoretical and analytical advances in molecular epidemiology

The standard research approaches developed for genetic epidemiology are not necessarily appropriate for epigenetic studies of common disease. My group has pioneered the development of methods and approaches for the optimal execution of population-based studies of epigenetic variation, emphasizing the importance of establishing a causal role in pathology for disease-associated epigenetic changes. Our work in this area has helped to reinforce how improved understanding of the molecular mechanisms underlying human health and disease are best achieved by carrying out studies of epigenetics in populations as a part of an integrated functional genomics strategy.

Murphy TM, Mill J. Epigenetics in health and disease: heralding the EWAS era. Lancet. 2014 Mar 12. pii: S0140-6736(14)60269-5.
Mill J, Heijmans B. From promises to practical strategies in epigenetic epidemiology. Nature Reviews Genetics. Nat Rev Genet. 2013 Aug;14(8):585-94.
Pidsley R, Y Wong CC, Volta M, Lunnon K, Mill J, Schalkwyk LC. A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics. 2013 May 1;14:293.
Heijmans BT, Mill J.Commentary: The seven plagues of epigenetic epidemiology. Int J Epidemiol. 2012 Feb;41(1):74-8

Publications

Books

Petronis A, Mill J (2011). Preface to the volume.

Journal articles

Clifton N (In Press). Enrichment of the local synaptic translatome for genetic risk associated with schizophrenia and autism spectrum disorder. Biological Psychiatry

Ori APS, Olde Loohuis LM, Guintivano J, Hannon E, Dempster E, St. Clair D, Bass NJ, McQuillin A, Mill J, Sullivan PF, et al (2024). Meta-analysis of epigenetic aging in schizophrenia reveals multifaceted relationships with age, sex, illness duration, and polygenic risk. Clinical Epigenetics, 16(1). Abstract.

Hannon E, Mill J, Dempster E, Walker E, Franklin A, Chioza B, Commins G, Davies J, Burrage J (2024). Quantifying the proportion of different cell types in the human cortex using DNA methylation profiles. BMC Biology

Doherty T, Dempster E, Hannon E, Mill J, Poulton R, Corcoran D, Sugden K, Williams B, Caspi A, Moffitt TE, et al (2023). A comparison of feature selection methodologies and learning algorithms in the development of a DNA methylation-based telomere length estimator. BMC Bioinformatics, 24(1).

Caspi A, Shireby G, Mill J, Moffitt TE, Sugden K, Hannon E (2023). Accelerated Pace of Aging in Schizophrenia: Five Case-Control Studies. Biological Psychiatry

Nabais MF, Gadd DA, Hannon E, Mill J, McRae AF, Wray NR (2023). An overview of DNA methylation-derived trait score methods and applications. Genome Biol, 24(1). Abstract. Author URL.

Fodder K, Murthy M, Rizzu P, Toomey CE, Hasan R, Humphrey J, Raj T, Lunnon K, Mill J, Heutink P, et al (2023). Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes. Acta Neuropathol, 146(1), 77-95. Abstract. Author URL.

Sugden K, Moffitt TE, Arpawong TE, Arseneault L, Belsky DW, Corcoran DL, Crimmins EM, Hannon E, Houts R, Mill JS, et al (2023). Cross-National and Cross-Generational Evidence That Educational Attainment May Slow the Pace of Aging in European-Descent Individuals. The Journals of Gerontology Series B, 78(8), 1375-1385.

Sellers A, Hudson S, Ledger J, Moorehouse C, Young C, Groeber I, Knight B, Mill J, Allard J, Shankar R, et al (2023). Designing genetic studies for people with intellectual disabilities: Practical lessons from a pilot study. JOURNAL OF POLICY AND PRACTICE IN INTELLECTUAL DISABILITIES, 20(2), 158-163. Author URL.

Murthy M, Rizzu P, Heutink P, Mill J, Lashley T, Bettencourt C (2023). Epigenetic Age Acceleration in Frontotemporal Lobar Degeneration: a Comprehensive Analysis in the Blood and Brain. Cells, 12(14). Abstract. Author URL.

Murthy M, Shireby G, Miki Y, Viré E, Lashley T, Warner TT, Mill J, Bettencourt C (2023). Epigenetic age acceleration is associated with oligodendrocyte proportions in MSA and control brain tissue. Neuropathol Appl Neurobiol, 49(1). Abstract. Author URL.

Alameda L, Liu Z, Sham PC, Aas M, Trotta G, Rodriguez V, Di Forti M, Stilo SA, Kandaswamy R, Arango C, et al (2023). Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis-findings from the EU-GEI study. Mol Psychiatry, 28(5), 2095-2106. Abstract. Author URL.

Pishva E, van den Hove DLA, Laroche V, Lvovs A, Roy A, Ortega G, Burrage J, Veidebaum T, Kanarik M, Mill J, et al (2023). Genome-wide DNA methylation analysis of aggressive behaviour: a longitudinal population-based study. J Child Psychol Psychiatry, 64(7), 998-1006. Abstract. Author URL.

Patel V, Mill J, Okonkwo OC, Salamat S, Li L, Raife T (2023). Global Energy Metabolism Deficit in Alzheimer Disease Brain. The Journal of Prevention of Alzheimer's Disease

Nho K, Risacher SL, Apostolova L, Bice PJ, Brosch J, Deardorff R, Faber K, Farlow MR, Foroud T, Gao S, et al (2023). Novel CYP1B1-RMDN2 Alzheimer's disease locus identified by genome-wide association analysis of cerebral tau deposition on PET. medRxiv Abstract. Author URL.

Lin S, Hannon E, Reppell M, Waring JF, Smaoui N, Pivorunas V, Guay H, Chanchlani N, Bewshea C, Bai BYH, et al (2023). Whole blood DNA methylation changes are associated with anti-TNF drug concentration in patients with Crohn's disease. J Crohns Colitis Abstract. Author URL.

Davies J, Franklin A, Walker E, Owens N, Bray N, Bamford RA, Commin G, Chioza B, Burrage J, Dempster E, et al (2022). 1. DEVELOPMENTAL TRAJECTORIES OF DNA METHYLATION IN NEURAL CELL POPULATIONS IN HUMAN CORTEX AND LINKS TO NEURODEVELOPMENTAL DISORDERS. European Neuropsychopharmacology, 63

Hannon E, Jeffries AR, Policicchio S, Viana J, Leung SK, Dempster E, Mill J (2022). 42. LEVERAGING a BESPOKE CORTICAL TRANSCRIPTOME TO ASSESS THE ROLE OF ALTERNATIVE SPLICING IN SCHIZOPHRENIA. European Neuropsychopharmacology, 63, e67-e68.

Bamford R, Jeffries AR, Walker E, Leung SK, Commin G, Davies JP, Dempster E, Hannon E, Mill J (2022). 67. LONG READ TRANSCRIPTOME SEQUENCING REVEALS ISOFORM DIVERSITY ACROSS HUMAN NEURODEVELOPMENT. European Neuropsychopharmacology, 63, e81-e82.

Hannon E, Davies J, Chioza B, Policicchio S, Burrage J, Commin G, Jeffries AR, Schalkwyk L, Dempster E, Mill J, et al (2022). 89. IDENTIFYING CELL-TYPE-SPECIFIC EPIGENETIC VARIATION IN THE CORTEX ASSOCIATED WITH SCHIZOPHRENIA. European Neuropsychopharmacology, 63, e93-e94.

Imm JL, Harvey J, Creese B, Chouliaras L, Dempster E, Ballard CG, O'Brien JT, Aarsland D, Mill J, Pishva E, et al (2022). A Role for Epigenetic Mechanisms in the Lewy Body Dementias. Alzheimer's & Dementia, 18(S3).

Stevenson AJ, McCartney DL, Gadd DA, Shireby G, Hillary RF, King D, Tzioras M, Wrobel N, McCafferty S, Murphy L, et al (2022). A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens. Eur J Neurosci, 56(9), 5637-5649. Abstract. Author URL.

Weymouth LS, Kouhsar MP, Creese B, Bergh S, Wedatilake Y, Torkamani A, Smith AR, Selbaek G, Sweet R, Ballard CG, et al (2022). An Epigenome‐wide association study of psychosis in Alzheimer's disease dorsolateral prefrontal cortex. Alzheimer's & Dementia, 18(S4).

Sugden K, Caspi A, Elliott ML, Bourassa KJ, Chamarti K, Corcoran DL, Hariri AR, Houts RM, Kothari M, Kritchevsky S, et al (2022). Association of Pace of Aging Measured by Blood-Based DNA Methylation with Age-Related Cognitive Impairment and Dementia. Neurology, 99(13), e1402-e1413. Abstract. Author URL.

van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra H-J, Bakker OB, Deelen P, et al (2022). Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat Genet, 54(3). Author URL.

Shireby G, Dempster EL, Policicchio S, Smith RG, Pishva E, Chioza B, Davies JP, Burrage J, Lunnon K, Seiler Vellame D, et al (2022). DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types. Nature Communications, 13(1). Abstract.

Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, Baccarelli A, Chamarti K, Gao X, Hannon E, et al (2022). DunedinPACE, a DNA methylation biomarker of the pace of aging. Elife, 11 Abstract. Author URL.

Pihlstrøm L, Shireby G, Geut H, Henriksen SP, Rozemuller AJM, Tunold J-A, Hannon E, Francis P, Thomas AJ, Love S, et al (2022). Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology. Nature Communications, 13(1). Abstract.

Flynn R, Washer S, Jeffries AR, Andrayas A, Shireby G, Kumari M, Schalkwyk LC, Mill J, Hannon E (2022). Evaluation of nanopore sequencing for epigenetic epidemiology: a comparison with DNA methylation microarrays. Hum Mol Genet, 31(18), 3181-3190. Abstract. Author URL.

Washer SJ, Flynn R, Oguro‐Ando A, Hannon E, Burrage J, Jeffries A, Mill J, Dempster EL (2022). Functional characterization of the schizophrenia associated gene <scp>AS3MT</scp> identifies a role in neuronal development. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 189(5), 151-162. Abstract.

Warrier V, Zhang X, Reed P, Havdahl A, Moore TM, Cliquet F, Leblond CS, Rolland T, Rosengren A, Caceres ASJ, et al (2022). Genetic correlates of phenotypic heterogeneity in autism. Nature Genetics, 54(9), 1293-1304. Abstract.

Devall M, Soanes DM, Smith AR, Dempster EL, Smith RG, Burrage J, Iatrou A, Hannon E, Troakes C, Moore K, et al (2022). Genome-wide characterization of mitochondrial DNA methylation in human brain. Front Endocrinol (Lausanne), 13 Abstract. Author URL.

Hop PJ, Zwamborn RAJ, Hannon E, Shireby GL, Nabais MF, Walker EM, van Rheenen W, van Vugt JJFA, Dekker AM, Westeneng H-J, et al (2022). Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS. Science Translational Medicine, 14(633). Abstract.

Ruf WP, Hannon E, Freischmidt A, Grozdanov V, Brenner D, Müller K, Knehr A, Günther K, Dorst J, Ammerpohl O, et al (2022). Methylome analysis of ALS patients and presymptomatic mutation carriers in blood cells. Neurobiol Aging, 116, 16-24. Abstract. Author URL.

Bao Y, Gorrie-Stone T, Hannon E, Hughes A, Andrayas A, Neilson G, Burrage J, Mill J, Schalkwyk L, Kumari M, et al (2022). Social mobility across the lifecourse and DNA methylation age acceleration in adults in the UK. Sci Rep, 12(1). Abstract. Author URL.

Wheildon G, Smith AR, Soanes D, Smith RG, Moore K, O'Neill P, Morgan K, Thomas AJ, Francis PT, Love S, et al (2022). Targeted bisulfite sequencing analysis of candidate genes associated with Alzheimer’s disease. Alzheimer's & Dementia, 18(S4).

Vellame DS, Shireby G, MacCalman A, Dempster EL, Burrage J, Gorrie-Stone T, Schalkwyk LS, Mill J, Hannon E (2022). Uncertainty quantification of reference-based cellular deconvolution algorithms. Epigenetics, 18(1).

Tielbeek JJ, Uffelmann E, Williams BS, Colodro-Conde L, Gagnon É, Mallard TT, Levitt BE, Jansen PR, Johansson A, Sallis HM, et al (2022). Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis. Mol Psychiatry, 27(11), 4453-4463. Abstract. Author URL.

van Heukelum S, Tulva K, Geers FE, van Dulm S, Ruisch IH, Mill J, Viana JF, Beckmann CF, Buitelaar JK, Poelmans G, et al (2021). A central role for anterior cingulate cortex in the control of pathological aggression. Curr Biol, 31(11), 2321-2333.e5. Abstract. Author URL.

Gunasekara CJ, Hannon E, MacKay H, Coarfa C, McQuillin A, Clair DS, Mill J, Waterland RA (2021). A machine learning case–control classifier for schizophrenia based on DNA methylation in blood. Translational Psychiatry, 11(1). Abstract.

Smith RG, Pishva E, Shireby G, Smith AR, Roubroeks JAY, Hannon E, Wheildon G, Mastroeni D, Gasparoni G, Riemenschneider M, et al (2021). A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex. Nat Commun, 12(1). Abstract. Author URL.

Imm JL, Harvey J, Pishva E, Creese B, Chouliaras L, Dempster E, Ballard C, O'Brien JT, Aarsland D, Mill J, et al (2021). A role for epigenetic mechanisms in Lewy body dementias. Alzheimers Dement, 17 Suppl 3 Abstract. Author URL.

Hannon E, Mansell G, Walker E, Nabais MF, Burrage J, Kepa A, Best-Lane J, Rose A, Heck S, Moffitt TE, et al (2021). Assessing the co-variability of DNA methylation across peripheral cells and tissues: Implications for the interpretation of findings in epigenetic epidemiology. PLoS Genet, 17(3). Abstract. Author URL.

Vellame DS, Castanho I, Dahir A, Mill J, Hannon E (2021). Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation. Abstract.

Seiler Vellame D, Castanho I, Dahir A, Mill J, Hannon E (2021). Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation. BMC Genomics, 22(1). Abstract. Author URL.

van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra H-J, Bakker OB, Deelen P, et al (2021). Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat Genet, 53(12), 1636-1648. Abstract. Author URL.

Hannon E, Dempster EL, Mansell G, Burrage J, Bass N, Bohlken MM, Corvin A, Curtis CJ, Dempster D, Di Forti M, et al (2021). DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia. Elife, 10 Abstract. Author URL.

Kandaswamy R, Hannon E, Arseneault L, Mansell G, Sugden K, Williams B, Burrage J, Staley JR, Pishva E, Dahir A, et al (2021). DNA methylation signatures of adolescent victimization: analysis of a longitudinal monozygotic twin sample. Epigenetics, 16(11), 1169-1186. Abstract. Author URL.

van Dongen J, Hagenbeek FA, Suderman M, Roetman PJ, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty JD, Adams MJ, et al (2021). DNA methylation signatures of aggression and closely related constructs: a meta-analysis of epigenome-wide studies across the lifespan. Mol Psychiatry, 26(6), 2148-2162. Abstract. Author URL.

Wang Y, Hannon E, Grant OA, Gorrie-Stone TJ, Kumari M, Mill J, Zhai X, McDonald-Maier KD, Schalkwyk LC (2021). DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy. BMC Genomics, 22(1). Abstract. Author URL.

Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, Baccarelli A, Chamarti K, Gao X, Hannon E, et al (2021). DunedinPACE: a DNA methylation biomarker of the Pace of Aging. Abstract.

Pihlstrøm L, Shireby G, Geut H, Henriksen SP, Rozemüller AJM, Tunold J-A, Hannon E, Francis P, Thomas AJ, Love S, et al (2021). Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology. Abstract.

Leung SK, Jeffries AR, Castanho I, Jordan BT, Moore K, Davies JP, Dempster EL, Bray NJ, O’Neill P, Tseng E, et al (2021). Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing. Cell Reports, 37(7), 110022-110022.

Hop PJ, Zwamborn RAJ, Hannon E, Shireby GL, Nabais MF, Walker EM, van Rheenen W, van Vugt JJFA, Dekker AM, Westeneng H-J, et al (2021). Genome-wide study of DNA methylation in Amyotrophic Lateral Sclerosis identifies differentially methylated loci and implicates metabolic, inflammatory and cholesterol pathways. Abstract.

Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, et al (2021). Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nat Genet, 53(9), 1311-1321. Abstract. Author URL.

van Dongen J, Gordon SD, McRae AF, Odintsova VV, Mbarek H, Breeze CE, Sugden K, Lundgren S, Castillo-Fernandez JE, Hannon E, et al (2021). Identical twins carry a persistent epigenetic signature of early genome programming. Nature Communications, 12(1). Abstract.

Nabais MF, Laws SM, Lin T, Vallerga CL, Armstrong NJ, Blair IP, Kwok JB, Mather KA, Mellick GD, Sachdev PS, et al (2021). Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome Biol, 22(1). Abstract. Author URL.

Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2021). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Mol Brain, 14(1). Abstract. Author URL.

Kouakou MR, Cameron D, Hannon E, Dempster EL, Mill J, Hill MJ, Bray NJ (2021). Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders. Am J Med Genet B Neuropsychiatr Genet, 186(6), 376-388. Abstract. Author URL.

Grodstein F, Lemos B, Yu L, Klein H-U, Iatrou A, Buchman AS, Shireby GL, Mill J, Schneider JA, De Jager PL, et al (2021). The association of epigenetic clocks in brain tissue with brain pathologies and common aging phenotypes. Neurobiol Dis, 157 Abstract. Author URL.

Smith AR, Smith RG, Macdonald R, Marzi SJ, Burrage J, Troakes C, Al-Sarraj S, Mill J, Lunnon K (2021). The histone modification H3K4me3 is altered at the ANK1 locus in Alzheimer's disease brain. Future Science OA, 7(4). Abstract.

Smith RG, Pishva E, Shireby G, Smith AR, Roubroeks JAY, Hannon E, Wheildon G, Mastroeni D, Gasparoni G, Riemenschneider M, et al (2020). A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex. Abstract.

Tazelaar GHP, Boeynaems S, De Decker M, van Vugt JJFA, Kool L, Goedee HS, McLaughlin RL, Sproviero W, Iacoangeli A, Moisse M, et al (2020). ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization. Brain Communications, 2(2). Abstract.

Roubroeks JAY, Smith AR, Smith RG, Pishva E, Ibrahim Z, Sattlecker M, Hannon EJ, Kłoszewska I, Mecocci P, Soininen H, et al (2020). An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. Neurobiol Aging, 95, 26-45. Abstract. Author URL.

Hannon E, Shireby G, Brookes KJ, Neilson G, Dahir A, Walker E, Lunnon K, Love S, Thomas AJ, Morgan K, et al (2020). An integrated epigenetic‐genetic study of neuropathology in the Brains for Dementia Research cohort. Alzheimer's & Dementia, 16(S2).

Hannon E, Mansell G, Burrage J, Kepa A, Best-Lane J, Rose A, Heck S, Moffitt T, Caspi A, Arseneault L, et al (2020). Assessing the co-variability of DNA methylation across peripheral cells and tissues: implications for the interpretation of findings in epigenetic epidemiology. Abstract.

Hannon E, Brookes KJ, Shireby G, Attems J, Sims R, Cairns NJ, Morgan K, Thomas AJ, Francis PT, Mill J, et al (2020). Assessment of the contribution of common genetic variants associated with Alzheimer’s disease on neuropathological burden and clinical characteristics in the Brains for Dementia Research cohort. Alzheimer's & Dementia, 16(S2).

Reuben A, Sugden K, Arseneault L, Corcoran DL, Danese A, Fisher HL, Moffitt TE, Newbury JB, Odgers C, Prinz J, et al (2020). Association of Neighborhood Disadvantage in Childhood with DNA Methylation in Young Adulthood. JAMA Netw Open, 3(6). Abstract. Author URL.

Reuben A, Sugden K, Arsenault L, Corcoran D, Danese A, Fisher HL, Moffitt TE, Newbury JB, Odgers C, Prinz J, et al (2020). Association of childhood neighborhood disadvantage with young adult DNA methylation. ISEE Conference Abstracts, 2020(1).

Leung SK, Jeffries A, Hannon E, Castanho I, Moore K, Murray TK, Ahmed Z, Collier DA, Mill J (2020). Characterization of mRNA isoform diversity in a transgenic model of tau pathology using targeted long‐read sequencing. Alzheimer's & Dementia, 16(S3).

Viana J, Wildman N, Hannon E, Farbos A, Neill PO, Moore K, van Aerle R, Paull G, Santos E, Mill J, et al (2020). Clozapine-induced transcriptional changes in the zebrafish brain. NPJ Schizophr, 6(1). Abstract. Author URL.

Hop PJ, Zwamborn RAJ, Hannon EJ, Dekker AM, van Eijk KR, Walker EM, Iacoangeli A, Jones AR, Shatunov A, Khleifat AA, et al (2020). Cross-reactive probes on Illumina DNA methylation arrays: a large study on ALS shows that a cautionary approach is warranted in interpreting epigenome-wide association studies. NAR Genomics and Bioinformatics, 2(4). Abstract.

Wang Y, Hannon E, Grant OA, Gorrie-Stone TJ, Kumari M, Mill J, Zhai X, McDonald-Maier KD, Schalkwyk LC (2020). DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy. Abstract.

Rovira P, Sánchez-Mora C, Pagerols M, Richarte V, Corrales M, Fadeuilhe C, Vilar-Ribó L, Arribas L, Shireby G, Hannon E, et al (2020). Epigenome-wide association study of attention-deficit/hyperactivity disorder in adults. Translational Psychiatry, 10(1). Abstract.

Jeffries AR, Leung SK, Castanho I, Moore K, Davies JP, Dempster EL, Bray NJ, O‘Neill P, Tseng E, Ahmed Z, et al (2020). Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex. Abstract.

Hannon E, Shireby GL, Brookes K, Attems J, Sims R, Cairns NJ, Love S, Thomas AJ, Morgan K, Francis PT, et al (2020). Genetic risk for Alzheimer’s disease influences neuropathology and cognition via multiple biological pathways. Abstract.

Hannon E, Shireby GL, Brookes K, Attems J, Sims R, Cairns NJ, Love S, Thomas AJ, Morgan K, Francis PT, et al (2020). Genetic risk for Alzheimer’s disease influences neuropathology via multiple biological pathways. Brain Communications, 2(2). Abstract.

Meijer M, Klein M, Hannon E, van der Meer D, Hartman C, Oosterlaan J, Heslenfeld D, Hoekstra PJ, Buitelaar J, Mill J, et al (2020). Genome-Wide DNA Methylation Patterns in Persistent Attention-Deficit/Hyperactivity Disorder and in Association with Impulsive and Callous Traits. Front Genet, 11 Abstract. Author URL.

Policicchio S, Washer S, Viana J, Iatrou A, Burrage J, Hannon E, Turecki G, Kaminsky Z, Mill J, Dempster EL, et al (2020). Genome-wide DNA methylation meta-analysis in the brains of suicide completers. Translational Psychiatry, 10(1). Abstract.

Castanho I, Murray TK, Leung SK, Hannon E, Jeffries A, Lunnon K, Ahmed Z, Mill J (2020). Genome‐wide DNA methylation signatures of tau and amyloid neuropathology. Alzheimer's & Dementia, 16(S3).

Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, et al (2020). Genomic and phenomic insights from an atlas of genetic effects on DNA methylation. Abstract.

Castanho I, Murray TK, Harvey J, Leung SK, Lunnon K, Ahmed Z, Mill J (2020). Global shifts in DNA methylation and DNA hydroxymethylation across multiple brain regions in transgenic models of tau and amyloid pathology. Alzheimer's & Dementia, 16(S2).

Chan RF, Shabalin AA, Montano C, Hannon E, Hultman CM, Fallin MD, Feinberg AP, Mill J, van den Oord EJCG, Aberg KA, et al (2020). Independent Methylome-Wide Association Studies of Schizophrenia Detect Consistent Case-Control Differences. Schizophr Bull, 46(2), 319-327. Abstract. Author URL.

Ramaswami G, Won H, Gandal MJ, Haney J, Wang JC, Wong CCY, Sun W, Prabhakar S, Mill J, Geschwind DH, et al (2020). Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism. Nature Communications, 11(1). Abstract.

Creese B, Malekizadeh Y, Williams G, Whitfield D, Kelson M, Ballard C, Mill J, Jeffries A (2020). In‐silico high throughput whole transcriptome screening implicates cardiovascular disease and the immune system in the mechanism of action underlying adverse effects of atypical antipsychotics. Alzheimer's & Dementia, 16(S9).

Mooney MA, Ryabinin P, Wilmot B, Bhatt P, Mill J, Nigg JT (2020). Large epigenome-wide association study of childhood ADHD identifies peripheral DNA methylation associated with disease and polygenic risk burden. Transl Psychiatry, 10(1). Abstract. Author URL.

Hannon E, Dempster EL, Mansell G, Burrage J, Bass N, Bohlken MM, Corvin A, Curtis CJ, Dempster D, Di Forta M, et al (2020). Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia. Abstract.

Sadahiro R, Knight B, James F, Hannon E, Charity J, Daniels IR, Burrage J, Knox O, Crawford B, Smart NJ, et al (2020). Major surgery induces acute changes in measured DNA methylation associated with immune response pathways. Sci Rep, 10(1). Abstract. Author URL.

Brann DH, Tsukahara T, Weinreb C, Lipovsek M, Van den Berge K, Gong B, Chance R, Macaulay IC, Chou H-J, Fletcher RB, et al (2020). Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. SCIENCE ADVANCES, 6(31). Author URL.

Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2020). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Abstract.

Sugden K, Hannon EJ, Arseneault L, Belsky DW, Corcoran DL, Fisher HL, Houts RM, Kandaswamy R, Moffitt TE, Poulton R, et al (2020). Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement. Patterns, 1(2), 100014-100014.

Pishva E, Creese B, Smith AR, Viechtbauer W, Proitsi P, van den Hove DLA, Ballard C, Mill J, Lunnon K (2020). Psychosis-associated DNA methylomic variation in Alzheimer's disease cortex. Neurobiology of Aging, 89, 83-88. Abstract.

Belsky DW, Caspi A, Arseneault L, Baccarelli A, Corcoran DL, Gao X, Hannon E, Harrington HL, Rasmussen LJH, Houts R, et al (2020). Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm. eLife, 9 Abstract.

Belsky DW, Caspi A, Arseneault L, Baccarelli A, Corcoran D, Gao X, Hannon E, Harrington HL, Rasmussen LJH, Houts R, et al (2020). Quantification of the pace of biological aging in humans through a blood test: the DunedinPoAm DNA methylation algorithm. Abstract.

Shireby GL, Davies JP, Francis PT, Burrage J, Walker EM, Neilson GWA, Dahir A, Thomas AJ, Love S, Smith RG, et al (2020). Recalibrating the Epigenetic Clock: Implications for Assessing Biological Age in the Human Cortex. Abstract.

Shireby GL, Davies JP, Francis PT, Burrage J, Walker EM, Neilson GWA, Dahir A, Thomas AJ, Love S, Smith RG, et al (2020). Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex. Brain, 143(12), 3763-3775. Abstract. Author URL.

Nabais MF, Lin T, Benyamin B, Williams KL, Garton FC, Vinkhuyzen AAE, Zhang F, Vallerga CL, Restuadi R, Freydenzon A, et al (2020). Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis. npj Genomic Medicine, 5(1). Abstract.

Smith AR, Mill J, Lunnon K (2020). The molecular etiology of Alzheimer’s disease. Brain Pathology, 30(5), 964-965. Abstract.

Tovy A, Reyes JM, Gundry MC, Brunetti L, Lee-Six H, Petljak M, Park HJ, Guzman AG, Rosas C, Jeffries AR, et al (2020). Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual is Associated with Conserved Epigenetic Erosion. Cell Stem Cell, 27(2), 326-335.e4. Abstract. Author URL.

Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, et al (2020). Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell Rep, 30(6), 2040-2054.e5. Abstract. Author URL.

Malekizadeh Y, Williams G, Kelson M, Whitfield D, Mill J, Collier DA, Ballard C, Jeffries AR, Creese B (2020). Whole transcriptome in silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side effects. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 6(1). Abstract.

Smith AR, Smith RG, Burrage J, Troakes C, Al-Sarraj S, Kalaria RN, Sloan C, Robinson AC, Mill J, Lunnon K, et al (2019). A cross-brain regions study of ANK1 DNA methylation in different neurodegenerative diseases. Neurobiology of Aging, 74, 70-76. Abstract.

Lardenoije R, Roubroeks JAY, Pishva E, Leber M, Wagner H, Iatrou A, Smith AR, Smith RG, Eijssen LMT, Kleineidam L, et al (2019). Alzheimer's disease-associated (hydroxy)methylomic changes in the brain and blood. Clin Epigenetics, 11(1). Abstract. Author URL.

Tazelaar GSHP, Dekker AM, van Vugt JJFA, van der Spek RA, Westeneng H-J, Kool LJBG, Kenna KP, van Rheenen W, Pulit SL, McLaughlin RL, et al (2019). Association of NIPA1 repeat expansions with amyotrophic lateral sclerosis in a large international cohort. NEUROBIOLOGY OF AGING, 74 Author URL.

Ori APS, Olde Loohuis LM, Guintivano J, Hannon E, Dempster E, St. Clair D, Bass NJ, McQuillin A, Mill J, Sullivan PF, et al (2019). Epigenetic age is accelerated in schizophrenia with age- and sex-specific effects and associated with polygenic disease risk. Abstract.

Migdalska-Richards A, Mill J (2019). Epigenetic studies of schizophrenia: current status and future directions. CURRENT OPINION IN BEHAVIORAL SCIENCES, 25, 102-110. Author URL.

van Dongen J, Zilhão NR, Sugden K, BIOS Consortium, Hannon EJ, Mill J, Caspi A, Agnew-Blais J, Arseneault L, Corcoran DL, et al (2019). Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults. Biol Psychiatry, 86(8), 599-607. Abstract. Author URL.

Sugden K, Hannon EJ, Arseneault L, Belsky DW, Broadbent JM, Corcoran DL, Hancox RJ, Houts RM, Moffitt TE, Poulton R, et al (2019). Establishing a generalized polyepigenetic biomarker for tobacco smoking. Transl Psychiatry, 9(1). Abstract. Author URL.

Polimanti R, Peterson RE, Ong J-S, MacGregor S, Edwards AC, Clarke T-K, Frank J, Gerring Z, Gillespie NA, Lind PA, et al (2019). Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium. PSYCHOLOGICAL MEDICINE, 49(7), 1218-1226. Author URL.

Hannon E, Marzi SJ, Schalkwyk LS, Mill J (2019). Genetic risk variants for brain disorders are enriched in cortical H3K27ac domains. Mol Brain, 12(1). Abstract. Author URL.

Belsky DW, Caspi A, Arseneault L, Corcoran DL, Domingue BW, Harris KM, Houts RM, Mill JS, Moffitt TE, Prinz J, et al (2019). Genetics and the geography of health, behaviour and attainment. Nat Hum Behav, 3(6), 576-586. Abstract. Author URL.

Wong CCY, Smith RG, Hannon E, Ramaswami G, Parikshak NN, Assary E, Troakes C, Poschmann J, Schalkwyk LC, Sun W, et al (2019). Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue. Hum Mol Genet, 28(13), 2201-2211. Abstract. Author URL.

Jeffries AR, Maroofian R, Salter CG, Chioza BA, Cross HE, Patton MA, Dempster E, Temple IK, Mackay DJG, Rezwan FI, et al (2019). Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging. Genome Res, 29(7), 1057-1066. Abstract. Author URL.

Mansell G, Gorrie-Stone TJ, Bao Y, Kumari M, Schalkwyk LS, Mill J, Hannon E (2019). Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array. BMC Genomics, 20(1). Abstract. Author URL.

Roberts S, Suderman M, Zammit S, Watkins SH, Hannon E, Mill J, Relton C, Arseneault L, Wong CCY, Fisher HL, et al (2019). Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences. Transl Psychiatry, 9(1). Abstract. Author URL.

Kowalec K, Hannon E, Mansell G, Burrage J, Ori APS, Ophoff RA, Mill J, Sullivan PF (2019). Methylation age acceleration does not predict mortality in schizophrenia. Transl Psychiatry, 9(1). Abstract. Author URL.

Smith RG, Pishva E, Shireby G, Smith AR, Hannon E, Sharp AJ, Mastroeni DF, Schalkwyk LC, Haroutunian V, Coleman PD, et al (2019). O4‐10‐06: INTEGRATED GENETIC‐EPIGENETIC ANALYSES OF ALZHEIMER'S DISEASE. Alzheimer's & Dementia, 15(7S_Part_24), p1261-p1261.

Smith AR, Smith RG, Pishva E, Hannon E, Roubroeks JAY, Burrage J, Troakes C, Al-Sarraj S, Sloan C, Mill J, et al (2019). Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease. Clin Epigenetics, 11(1). Abstract. Author URL.

Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S, Cameron D, Hamshere ML, et al (2019). Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection (Nature Genetics, (2018), 50, 3, (381-389), 10.1038/s41588-018-0059-2). Nature Genetics, 51(7). Abstract.

Saffari A, Arno M, Nasser E, Ronald A, Wong CCY, Schalkwyk LC, Mill J, Dudbridge F, Meaburn EL (2019). RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation. Mol Autism, 10 Abstract. Author URL.

El Khoury LY, Gorrie-Stone T, Smart M, Hughes A, Bao Y, Andrayas A, Burrage J, Hannon E, Kumari M, Mill J, et al (2019). Systematic underestimation of the epigenetic clock and age acceleration in older subjects. Genome Biol, 20(1). Abstract. Author URL.

Hughes A, Bao Y, Smart M, Gorrie-Stone T, Hannon E, Mill J, Burrage J, Schalkwyk L, Kumari M (2019). THE AUTHORS REPLY. American Journal of Epidemiology, 188(2), 488-489.

Castanho I, Murray T, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Randall A, Moore K, et al (2019). Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid Pathology.

Hannon E, Schendel D, Ladd-Acosta C, Grove J, Hansen CS, Hougaard DM, Bresnahan M, Mors O, Hollegaard MV, Bækvad-Hansen M, et al (2019). Variable DNA methylation in neonates mediates the association between prenatal smoking and birth weight. Philosophical Transactions of the Royal Society B: Biological Sciences, 374(1770). Abstract.

Marzi SJ, Leung SK, Ribarska T, Hannon E, Smith AR, Pishva E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, et al (2018). A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex. Nature Neuroscience, 21(11), 1618-1627. Abstract.

Marzi SJ, Sugden K, Arsenault L, Belsky DW, Burrage J, Corcoran DL, Danese A, Fisher HL, Hannon EJ, Moffitt TE, et al (2018). Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood. American Journal of Psychiatry

Luijk R, Wu H, Ward-Caviness CK, Hannon E, Carnero-Montoro E, Min JL, Mandaviya P, Müller-Nurasyid M, Mei H, van der Maarel SM, et al (2018). Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation. Nature Communications, 9(1). Abstract. Author URL.

Gorrie-Stone TJ, Smart MC, Saffari A, Malki K, Hannon E, Burrage J, Mill J, Kumari M, Schalkwyk LC (2018). Bigmelon: tools for analysing large DNA methylation datasets. Bioinformatics, bty713-bty713. Abstract. Author URL.

Hannon E, Knox O, Sugden K, Burrage J, Wong CCY, Belsky DW, Corcoran DL, Arseneault L, Moffitt TE, Caspi A, et al (2018). Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins. PLoS Genetics, 14(8). Abstract.

Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S, Cameron D, Hamshere ML, et al (2018). Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics, 50(3), 381-389. Abstract.

Mastroeni D, Sekar S, Nolz J, Delvaux E, Lunnon K, Mill J, Liang WS, Coleman PD (2018). Correction: ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity. PLoS One, 13(1). Abstract. Author URL.

Crawford B, Craig Z, Mansell G, White I, Smith A, Spaull S, Imm J, Hannon E, Wood A, Yaghootkar H, et al (2018). DNA methylation and inflammation marker profiles associated with a history of depression. Human Molecular Genetics, 27(16), 2840-2850. Abstract.

Smith RG, Hannon E, De Jager PL, Chibnik L, Lott SJ, Condliffe D, Smith AR, Haroutunian V, Troakes C, Al-Sarraj S, et al (2018). Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology. Alzheimers Dement, 14(12), 1580-1588. Abstract. Author URL.

Hannon E, Schendel D, Ladd-Acosta C, Grove J, Hansen CS, Andrews SV, Hougaard DM, Bresnahan M, Mors O, Hollegaard MV, et al (2018). Elevated polygenic burden for autism is associated with differential DNA methylation at birth. Genome Medicine, 10(1). Abstract. Author URL.

O'Brien HE, Hannon E, Hill MJ, Toste CC, Robertson MJ, Morgan JE, McLaughlin G, Lewis CM, Schalkwyk LC, Hall LS, et al (2018). Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders. Genome Biol, 19(1). Abstract. Author URL.

Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, et al (2018). Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. NEURON, 97(6), 1268-+. Author URL.

Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, et al (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet, 50(5), 668-681. Abstract. Author URL.

Clissold RL, Ashfield B, Burrage J, Hannon E, Bingham C, Mill J, Hattersley A, Dempster EL (2018). Genome-wide methylomic analysis in individuals with HNF1B intragenic mutation and 17q12 microdeletion. Clin Epigenetics, 10(1). Abstract. Author URL.

Hannon E, Gorrie-Stone TJ, Smart MC, Burrage J, Hughes A, Bao Y, Kumari M, Schalkwyk LC, Mill J (2018). Leveraging DNA-Methylation Quantitative-Trait Loci to Characterize the Relationship between Methylomic Variation, Gene Expression, and Complex Traits. American Journal of Human Genetics, 103(5), 654-665. Abstract.

Rutten BPF, Vermetten E, Vinkers CH, Ursini G, Daskalakis NP, Pishva E, de Nijs L, Houtepen LC, Eijssen L, Jaffe AE, et al (2018). Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder. Mol Psychiatry, 23(5), 1145-1156. Abstract. Author URL.

Marioni RE, McRae AF, Bressler J, Colicino E, Hannon E, Li S, Prada D, Smith JA, Trevisi L, Tsai P-C, et al (2018). Meta-analysis of epigenome-wide association studies of cognitive abilities. Mol Psychiatry, 23(11), 2133-2144. Abstract. Author URL.

Creese B, Pishva E, Proitsi P, Smith RG, Ballard C, van den Hove DLA, Mill J, Lunnon K (2018). P2‐143: PSYCHOSIS‐ASSOCIATED EPIGENETIC VARIATION IN PATIENTS WITH ALZHEIMER'S DISEASE ACROSS CORTICAL BRAIN REGIONS. Alzheimer's & Dementia, 14(7S_Part_13), p723-p723.

Chouliaras L, Pishva E, Haapakoski R, Zsoldos E, Mahmood A, Filippini N, Burrage J, Mill J, Kivimäki M, Lunnon K, et al (2018). Peripheral DNA methylation, cognitive decline and brain aging: pilot findings from the Whitehall II imaging study. Epigenomics, 10(5), 585-595. Abstract. Author URL.

Basil P, Li Q, Gui H, Hui TCK, Ling VHM, Wong CCY, Mill J, McAlonan GM, Sham P-C (2018). Prenatal immune activation alters the adult neural epigenome but can be partly stabilised by a n-3 polyunsaturated fatty acid diet. Transl Psychiatry, 8(1). Abstract. Author URL.

O’Brien HE, Hannon E, Jeffries AR, Davies W, Hill MJ, Anney RJ, O’Donovan MC, Mill J, Bray NJ (2018). Sex differences in gene expression in the human fetal brain. Abstract.

Laing LV, Viana J, Dempster EL, Uren Webster TM, van Aerle R, Mill J, Santos EM (2018). Sex-specific transcription and DNA methylation profiles of reproductive and epigenetic associated genes in the gonads and livers of breeding zebrafish. Comp Biochem Physiol a Mol Integr Physiol, 222, 16-25. Abstract. Author URL.

Hughes A, Smart M, Gorrie-Stone T, Hannon E, Mill J, Bao Y, Burrage J, Schalkwyk L, Kumari M (2018). Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course. Am J Epidemiol, 187(11), 2346-2354. Abstract. Author URL.

Spiers H, Hannon EJ, Schalkwyk LS, Bray NJ, Mill J (2017). 5-hydroxymethylcytosine is highly dynamic across human fetal brain development. BMC Genomics, 18, 738-738.

Marzi SJ, Ribarska T, Smith AR, Hannon E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, Beck S, Newman S, et al (2017). A histone acetylome-wide association study of Alzheimer’s disease: neuropathology-associated regulatory variation in the human entorhinal cortex. Abstract.

Mastroeni D, Sekar S, Nolz J, Delvaux E, Lunnon K, Mill J, Liang WS, Coleman PD (2017). ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity. PLoS One, 12(7). Abstract. Author URL.

Janecka M, Mill J, Basson MA, Goriely A, Spiers H, Reichenberg A, Schalkwyk L, Fernandes C (2017). Advanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms. Transl Psychiatry, 7(1). Abstract. Author URL.

Roberts S, Suderman M, Zammit S, Watkins SH, Hannon E, Relton C, Mill J, Fisher HL (2017). DNA methylation and adolescent trajectories of psychotic symptoms. European Neuropsychopharmacology, 27, S886-S886.

Walton E, Pingault J-B, Cecil CAM, Gaunt TR, Relton CL, Mill J, Barker ED (2017). Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study. Mol Psychiatry, 22(2), 250-256. Abstract. Author URL.

Lu AT, Hannon E, Levine ME, Crimmins EM, Lunnon K, Mill J, Geschwind DH, Horvath S (2017). Genetic architecture of epigenetic and neuronal ageing rates in human brain regions. Nat Commun, 8 Abstract. Author URL.

Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, et al (2017). Genetic variation at 16q24.2 is associated with small vessel stroke. Ann Neurol, 81(3), 383-394. Abstract. Author URL.

Gillespie AL, Samanaite R, Mill J, Egerton A, MacCabe JH (2017). Is treatment-resistant schizophrenia categorically distinct from treatment-responsive schizophrenia? a systematic review. BMC Psychiatry, 17(1). Abstract. Author URL.

Murphy TM, Crawford B, Dempster EL, Hannon E, Burrage J, Turecki G, Kaminsky Z, Mill J (2017). Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide. Transl Psychiatry, 7(1). Abstract. Author URL.

Janecka M, Haworth CMA, Ronald A, Krapohl E, Happé F, Mill J, Schalkwyk LC, Fernandes C, Reichenberg A, Rijsdijk F, et al (2017). Paternal Age Alters Social Development in Offspring. J Am Acad Child Adolesc Psychiatry, 56(5), 383-390. Abstract. Author URL.

Hannon E, Weedon M, Bray N, O'Donovan M, Mill J (2017). Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci. Am J Hum Genet, 100(6), 954-959. Abstract. Author URL.

Jeffries AR, Mill J (2017). Profiling Regulatory Variation in the Brain: Methods for Exploring the Neuronal Epigenome. Biol Psychiatry, 81(2), 90-91. Author URL.

Mifsud KR, Saunderson EA, Spiers H, Carter SD, Trollope AF, Mill J, Reul JMHM (2017). Rapid Down-Regulation of Glucocorticoid Receptor Gene Expression in the Dentate Gyrus after Acute Stress in vivo: Role of DNA Methylation and MicroRNA Activity. NEUROENDOCRINOLOGY, 104(2), 157-169. Author URL.

Devall M, Smith RG, Jeffries A, Hannon E, Davies MN, Schalkwyk L, Mill J, Weedon M, Lunnon K (2017). Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue. Clin Epigenetics, 9 Abstract. Author URL.

Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). SU116. Longitudinal Epigenetic Analysis of Clozapine Use in Treatment-Resistant Schizophrenia. Schizophrenia Bulletin, 43(suppl_1), s203-s203.

Viana J, Hannon E, Dempster E, Pidsley R, Macdonald R, Knox O, Spiers H, Troakes C, Al-Saraj S, Turecki G, et al (2017). Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions. Hum Mol Genet, 26(1), 210-225. Abstract. Author URL.

Cooper-Knock J, Robins H, Niedermoser I, Wyles M, Heath PR, Higginbottom A, Walsh T, Kazoka M, Al Kheifat A, Al-Chalabi A, et al (2017). Targeted genetic screen in amyotrophic lateral sclerosis reveals novel genetic variants with synergistic effect on clinical phenotype. Frontiers in Molecular Neuroscience, 10 Abstract.

Castanho IMS, Murray TK, Farbos A, Lunnon K, Collier DA, Ahmed Z, Paszkiewicz K, O'Neill MJ, Mill J (2017). [P1–144]: TRANSCRIPTIONAL AND EPIGENOMIC PROFILING IN THE ENTORHINAL CORTEX IN AMYLOID AND TAU MOUSE MODELS OF ALZHEIMER's DISEASE. Alzheimer's & Dementia, 13(7S_Part_6), p298-p298.

Spiers H, Hannon E, Wells S, Williams B, Fernandes C, Mill J (2016). Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. Mech Ageing Dev, 154, 20-23. Abstract. Author URL.

Rijlaarsdam J, Pappa I, Walton E, Bakermans-Kranenburg MJ, Mileva-Seitz VR, Rippe RCA, Roza SJ, Jaddoe VWV, Verhulst FC, Felix JF, et al (2016). An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: a model approach for replication. Epigenetics, 11(2), 140-149. Abstract. Author URL.

Hannon E, Dempster E, Viana J, Burrage J, Smith AR, Macdonald R, St Clair D, Mustard C, Breen G, Therman S, et al (2016). An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biol, 17(1). Abstract. Author URL.

Laing LV, Viana J, Dempster EL, Trznadel M, Trunkfield LA, Uren Webster TM, van Aerle R, Paull GC, Wilson RJ, Mill J, et al (2016). Bisphenol a causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Epigenetics, 11(7), 526-538. Abstract. Author URL.

Richardson TG, Shihab HA, Hemani G, Zheng J, Hannon E, Mill J, Carnero-Montoro E, Bell JT, Lyttleton O, McArdle WL, et al (2016). Collapsed methylation quantitative trait loci analysis for low frequency and rare variants. Hum Mol Genet, 25(19), 4339-4349. Abstract. Author URL.

McDermott E, Ryan EJ, Tosetto M, Gibson D, Burrage J, Keegan D, Byrne K, Crowe E, Sexton G, Malone K, et al (2016). DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis. J Crohns Colitis, 10(1), 77-86. Abstract. Author URL.

Cecil CAM, Walton E, Smith RG, Viding E, McCrory EJ, Relton CL, Suderman M, Pingault J-B, McArdle W, Gaunt TR, et al (2016). DNA methylation and substance-use risk: a prospective, genome-wide study spanning gestation to adolescence. Transl Psychiatry, 6(12). Abstract. Author URL.

Smith AR, Mill J, Smith RG, Lunnon K (2016). Elucidating novel dysfunctional pathways in Alzheimer's disease by integrating loci identified in genetic and epigenetic studies. Neuroepigenetics, 6, 32-50. Abstract.

Bakulski KM, Halladay A, Hu VW, Mill J, Fallin MD (2016). Epigenetic Research in Neuropsychiatric Disorders: the "Tissue Issue". Curr Behav Neurosci Rep, 3(3), 264-274. Abstract. Author URL.

Devall M, Roubroeks J, Mill J, Weedon M, Lunnon K (2016). Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies. Neurosci Lett, 625, 47-55. Abstract. Author URL.

Cecil CAM, Smith RG, Walton E, Mill J, McCrory EJ, Viding E (2016). Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability. J Psychiatr Res, 83, 184-194. Abstract. Author URL.

Jeffries AR, Uwanogho DA, Cocks G, Perfect LW, Dempster E, Mill J, Price J (2016). Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming. RNA, 22(10), 1620-1630. Abstract. Author URL.

Lunnon K, Hannon E, G.Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum [Genome Biol. 2016, 17, 27]. Genome Biology, 17(1).

Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S, et al (2016). Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nat Commun, 7 Abstract. Author URL.

Houtepen LC, Vinkers CH, Carrillo-Roa T, Hiemstra M, van Lier PA, Meeus W, Branje S, Heim CM, Nemeroff CB, Mill J, et al (2016). Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans. Nat Commun, 7 Abstract. Author URL.

Sun W, Poschmann J, Cruz-Herrera Del Rosario R, Parikshak NN, Hajan HS, Kumar V, Ramasamy R, Belgard TG, Elanggovan B, Wong CCY, et al (2016). Histone Acetylome-wide Association Study of Autism Spectrum Disorder. Cell, 167(5), 1385-1397.e11. Abstract. Author URL.

Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract. Author URL.

Cizmeci D, Dempster EL, Champion OL, Wagley S, Akman OE, Prior JL, Soyer OS, Mill J, Titball RW (2016). Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection. Sci Rep, 6 Abstract. Author URL.

Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G, O'Donovan MC, Schalkwyk LC, et al (2016). Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. NATURE NEUROSCIENCE, 19(1), 48-+. Author URL.

Wilmot B, Fry R, Smeester L, Musser ED, Mill J, Nigg JT (2016). Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2. J Child Psychol Psychiatry, 57(2), 152-160. Abstract. Author URL.

Smith A, Smith R, Roubroeks J, Hannon E, Burrage J, Troakes C, van den Hove D, Mill J, Lunnon K (2016). O2‐06‐05: Hydroxymethylomic Profiling Implicates Cortical Deregulation of ANK1 and APP in the Alzheimer's Disease Brain. Alzheimer's & Dementia, 12(7S_Part_5), p240-p241.

Kumsta R, Marzi SJ, Viana J, Dempster EL, Crawford B, Rutter M, Mill J, Sonuga-Barke EJS (2016). Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1. Transl Psychiatry, 6(6). Abstract. Author URL.

Saunderson EA, Spiers H, Mifsud KR, Gutierrez-Mecinas M, Trollope AF, Shaikh A, Mill J, Reul JMHM (2016). Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus. Proc Natl Acad Sci U S A, 113(17), 4830-4835. Abstract. Author URL.

Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J, et al (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics, 11(1), 24-35. Abstract. Author URL.

Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract. Author URL.

Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K (2015). A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders. Biotechniques, 59(4), 241-246. Abstract. Author URL.

Hannon E, Chand AN, Evans MD, Wong CCY, Grubb MS, Mill J (2015). A role for CaV1 and calcineurin signaling in depolarization-induced changes in neuronal DNA methylation. Neuroepigenetics, 3, 1-6.

Ruggeri B, Nymberg C, Vuoksimaa E, Lourdusamy A, Wong CP, Carvalho FM, Jia T, Cattrell A, Macare C, Banaschewski T, et al (2015). Association of Protein Phosphatase PPM1G with Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis. Am J Psychiatry, 172(6), 543-552. Abstract. Author URL.

Lunnon K, Smith RG, Cooper I, Greenbaum L, Mill J, Beeri MS (2015). Blood methylomic signatures of presymptomatic dementia in elderly subjects with type 2 diabetes mellitus. Neurobiology of Aging, 36(3), 1600.e1-1600.e4. Abstract.

Oh G, Wang S-C, Pal M, Chen ZF, Khare T, Tochigi M, Ng C, Yang YA, Kwan A, Kaminsky ZA, et al (2015). DNA modification study of major depressive disorder: beyond locus-by-locus comparisons. Biol Psychiatry, 77(3), 246-255. Abstract. Author URL.

Spiers H, Bray NJ, Hannon E, Schalkwyk LC, Wong CC, Pidsley R, Smith RG, Mill J (2015). Dynamic and sex-specific changes in DNA methylation during human fetal brain development. Int J Dev Neurosci, 47(Pt A), 50-51. Author URL.

Janecka M, Manduca A, Servadio M, Trezza V, Smith R, Mill J, Schalkwyk LC, Reichenberg A, Fernandes C (2015). Effects of advanced paternal age on trajectories of social behavior in offspring. Genes Brain Behav, 14(6), 443-453. Abstract. Author URL.

Wong CCY, Parsons MJ, Lester KJ, Burrage J, Eley TC, Mill J, Dempster EL, Gregory AM (2015). Epigenome-Wide DNA Methylation Analysis of Monozygotic Twins Discordant for Diurnal Preference. Twin Res Hum Genet, 18(6), 662-669. Abstract. Author URL.

Collier D, Achilla E, Breen G, Curran S, Dima D, Flanagan R, Frank J, Frangou S, Gasse C, Giegling I, et al (2015). How can Pharmacogenomics Biomarkers be Translated into Patient Benefit. EUROPEAN PSYCHIATRY, 30 Author URL.

Hannon E, Lunnon K, Schalkwyk L, Mill J (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics, 10(11), 1024-1032. Abstract. Author URL.

Elliott G, Hong C, Xing X, Zhou X, Li D, Coarfa C, Bell RJA, Maire CL, Ligon KL, Sigaroudinia M, et al (2015). Intermediate DNA methylation is a conserved signature of genome regulation. Nat Commun, 6 Abstract. Author URL.

Fisher HL, Caspi A, Moffitt TE, Wertz J, Gray R, Newbury J, Ambler A, Zavos H, Danese A, Mill J, et al (2015). Measuring adolescents' exposure to victimization: the Environmental Risk (E-Risk) Longitudinal Twin Study. Dev Psychopathol, 27(4 Pt 2), 1399-1416. Abstract. Author URL.

Fisher HL, Murphy TM, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, et al (2015). Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. Epigenetics, 10(11), 1014-1023. Abstract. Author URL.

Murphy TM, Wong CCY, Arseneault L, Burrage J, Macdonald R, Hannon E, Fisher HL, Ambler A, Moffitt TE, Caspi A, et al (2015). Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins. Clin Epigenetics, 7 Abstract. Author URL.

McDermott E, Ryan E, Tosetto M, Burrage J, Mill J, Doherty G, Cullen G, Mulcahy H, Murphy T (2015). Methylomic profiling in Inflammatory Bowel Disease: New insights into disease pathogenesis and activity. JOURNAL OF CROHNS & COLITIS, 9, S430-S430. Author URL.

Spiers H, Hannon E, Schalkwyk LC, Smith R, Wong CCY, O'Donovan MC, Bray NJ, Mill J (2015). Methylomic trajectories across human fetal brain development. Genome Res, 25(3), 338-352. Abstract. Author URL.

PsychENCODE Consortium, Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, et al (2015). The PsychENCODE project. Nat Neurosci, 18(12), 1707-1712. Abstract. Author URL.

De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, et al (2014). Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci, 17(9), 1156-1163. Abstract. Author URL.

Silva PN, Furuya TK, Braga IL, Rasmussen LT, Labio RW, Bertolucci PH, Chen ES, Turecki G, Mechawar N, Payao SL, et al (2014). Analysis of HSPA8 and HSPA9 mRNA Expression and Promoter Methylation in the Brain and Blood of Alzheimer's Disease Patients. JOURNAL OF ALZHEIMERS DISEASE, 38(1), 165-170. Author URL.

Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, et al (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiology of Aging, 35(8), 1850-1854. Abstract.

Bell JT, Loomis AK, Butcher LM, Gao F, Zhang B, Hyde CL, Sun J, Wu H, Ward K, Harris J, et al (2014). Differential methylation of the TRPA1 promoter in pain sensitivity. Nature Communications, 5 Abstract.

Cecil CAM, Lysenko LJ, Jaffee SR, Pingault J-B, Smith RG, Relton CL, Woodward G, McArdle W, Mill J, Barker ED, et al (2014). Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study. Mol Psychiatry, 19(10), 1071-1077. Abstract. Author URL.

Fitzsimons CP, Van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, Van Den Hurk M, Boks MP, Biojone C, Joca S, et al (2014). Epigenetic regulation of adult neural stem cells: Implications for Alzheimer's disease. Molecular Neurodegeneration, 9(1). Abstract.

Van den Hove DL, Kompotis K, Lardenoije R, Kenis G, Mill J, Steinbusch HW, Lesch K-P, Fitzsimons CP, De Strooper B, Rutten BPF, et al (2014). Epigenetically regulated microRNAs in Alzheimer's disease. Neurobiol Aging, 35(4), 731-745. Abstract. Author URL.

Murphy TM, Mill J (2014). Epigenetics in health and disease: Heralding the EWAS era. The Lancet, 383(9933), 1952-1954.

Murphy TM, Mill J (2014). Epigenetics in health and disease: heralding the EWAS era. Lancet, 383(9933), 1952-1954. Author URL.

Viana J, Pidsley R, Troakes C, Spiers H, Wong CC, Al-Sarraj S, Craig I, Schalkwyk L, Mill J (2014). Epigenomic and transcriptomic signatures of a Klinefelter syndrome (47,XXY) karyotype in the brain. Epigenetics, 9(4), 587-599. Abstract. Author URL.

Basil P, Li Q, Dempster EL, Mill J, Sham P-C, Wong CCY, McAlonan GM (2014). Erratum: Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Translational Psychiatry, 4(9), e455-e455.

Dempster EL, Wong CCY, Lester KJ, Burrage J, Gregory AM, Mill J, Eley TC (2014). Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression. Biological Psychiatry, 76(12), 977-983. Abstract.

Davies MN, Krause L, Bell JT, Gao F, Ward KJ, Wu H, Lu H, Liu Y, Tsai P-C, Collier DA, et al (2014). Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. GENOME BIOLOGY, 15(4). Author URL.

Ilott NE, Schneider T, Mill J, Schalkwyk L, Brolese G, Bizarro L, Stolerman IP, Dempster E, Asherson P (2014). Long-term effects of gestational nicotine exposure and food-restriction on gene expression in the striatum of adolescent rats. PLoS One, 9(2). Abstract. Author URL.

Wong CCY, Meaburn EL, Ronald A, Price TS, Jeffries AR, Schalkwyk LC, Plomin R, Mill J (2014). Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol Psychiatry, 19(4), 495-503. Abstract. Author URL.

Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract. Author URL.

Pidsley R, Viana J, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk LC, Bray NJ, et al (2014). Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. GENOME BIOLOGY, 15(10). Author URL.

Basil P, Li Q, Dempster EL, Mill J, Sham P-C, Wong CCY, McAlonan GM (2014). Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Transl Psychiatry, 4(9). Abstract. Author URL.

Devall M, Mill J, Lunnon K (2014). The mitochondrial epigenome: a role in Alzheimer's disease?. Epigenomics, 6(6), 665-675. Abstract. Author URL.

Smith RG, Fernandes C, Kember R, Schalkwyk LC, Buxbaum J, Reichenberg A, Mill J (2014). Transcriptomic changes in the frontal cortex associated with paternal age. Mol Autism, 5(1). Abstract. Author URL.

Silva PN, Furuya TK, Braga IS, Rasmussen LT, de Labio RW, Bertolucci PH, Chen ES, Turecki G, Mechawar N, Payao SL, et al (2013). CNP and DPYSL2 mRNA Expression and Promoter Methylation Levels in Brain of Alzheimer's Disease Patients. JOURNAL OF ALZHEIMERS DISEASE, 33(2), 349-355. Author URL.

Pidsley R, Y Wong CC, Volta M, Lunnon K, Mill J, Schalkwyk LC (2013). A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics, 14 Abstract. Author URL.

Smith RG, Reichenberg A, Kember RL, Buxbaum JD, Schalkwyk LC, Fernandes C, Mill J (2013). Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease. Mol Psychiatry, 18(6), 635-636. Author URL.

Moffitt TE, Arseneault L, Danese A, Fisher H, Mill J, Pariante C, Baucom D, Caspi A, Chen E, Miller G, et al (2013). Childhood exposure to violence and lifelong health: Clinical intervention science and stress-biology research join forces. Development and Psychopathology, 25(4), 1619-1634. Abstract.

Powell TR, Smith RG, Hackinger S, Schalkwyk LC, Uher R, McGuffin P, Mill J, Tansey KE (2013). DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP. Transl Psychiatry, 3(9). Abstract. Author URL.

Barros M, Dempster EL, Illott N, Chabrawi S, Maior RS, Tomaz C, Silva MADS, Huston JP, Mill J, Müller CP, et al (2013). Decreased methylation of the NK3 receptor coding gene (TACR3) after cocaine-induced place preference in marmoset monkeys. Addict Biol, 18(3), 452-454. Abstract. Author URL.

Lunnon KS, Mill J (2013). Epigenetic studies in Alzheimer’s disease: current findings, caveats and considerations for future studies. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 162, Issue 8, 789-799.

Dempster E, Viana J, Pidsley R, Mill J (2013). Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future. Schizophr Bull, 39(1), 11-16. Abstract. Author URL.

Shalev I, Moffitt TE, Sugden K, Williams B, Houts RM, Danese A, Mill J, Arseneault L, Caspi A (2013). Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study. MOLECULAR PSYCHIATRY, 18(5), 576-581. Author URL.

Mill J, Heijmans BT (2013). From promises to practical strategies in epigenetic epidemiology. Nat Rev Genet, 14(8), 585-594. Abstract. Author URL.

Melas PA, Wei Y, Wong CCY, Sjoholm LK, Aberg E, Mill J, Schalling M, Forsell Y, Lavebratt C (2013). Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 16(7), 1513-1528. Author URL.

Ouellet-Morin I, Wong CCY, Danese A, Pariante CM, Papadopoulos AS, Mill J, Arseneault L (2013). Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins. Psychol Med, 43(9), 1813-1823. Abstract. Author URL.

Curran S, Aitchison KJ, Paya-Cano J, Witt S, Lafuente A, Price T, Mill J, Santosh P, Rietschel M, Craig IW, et al (2013). Pharmacogenomic studies in children and young people to elucidate biomarkers of suicidality: establishing the biological sampling methodology as a prerequisite. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 22, S97-S97. Author URL.

Rommel A-S, Halperin JM, Mill J, Asherson P, Kuntsi J (2013). Protection from genetic diathesis in attention-deficit/hyperactivity disorder: possible complementary roles of exercise. J Am Acad Child Adolesc Psychiatry, 52(9), 900-910. Abstract. Author URL.

Pjetri E, Dempster E, Collier DA, Treasure J, Kas MJ, Mill J, Campbell IC, Schmidt U (2013). Quantitative promoter DNA methylation analysis of four candidate genes in anorexia nervosa: a pilot study. J Psychiatr Res, 47(2), 280-282. Author URL.

Saunderson EA, Trollope AF, Gutierrez-Mecinas M, Shaikh AA, Spiers H, Mill J, Reul JMHM (2013). S-Adenosyl-methionine impairs forced swimming-induced behavioural immobility by inhibiting gene expression in dentate gyrus neurons. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 23, S169-S169. Author URL.

Furuya TK, Oliveira da Silva PN, Marques Payao SL, Rasmussen LT, de Labio RW, Ferreira Bertolucci PH, Sampaio Braga IL, Chen ES, Turecki G, Mechawar N, et al (2012). SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's Disease. NEUROCHEMISTRY INTERNATIONAL, 61(7), 973-975. Author URL.

Docherty SJ, Davis OS, Haworth CM, Plomin R, D'Souza U, Mill J (2012). A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs. Behav Brain Funct, 8 Abstract. Author URL.

Kaminsky Z, Tochigi M, Jia P, Pal M, Mill J, Kwan A, Ioshikhes I, Vincent JB, Kennedy JL, Strauss J, et al (2012). A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder. MOLECULAR PSYCHIATRY, 17(7), 728-740. Author URL.

Furuya TK, Silva PNO, Payao SLM, Bertolucci PHF, Rasmussen LT, De Labio RW, Braga ILS, Chen ES, Turecki G, Mechawar N, et al (2012). ANALYSIS OF SNAP25 mRNA EXPRESSION AND PROMOTER DNA METHYLATION IN BRAIN AREAS OF ALZHEIMER'S DISEASE PATIENTS. NEUROSCIENCE, 220, 41-46. Author URL.

Zavos HMS, Wong CCY, Barclay NL, Keers R, Mill J, Rijsdijk FV, Gregory AM, Eley TC (2012). Anxiety sensitivity in adolescence and young adulthood: the role of stressful life events, 5HTTLPR and their interaction. Depression and Anxiety, 29(5), 400-408. Abstract.

Zavos HM, Wong CC, Barclay NL, Keers R, Mill J, Rijsdijk FV, Gregory AM, Eley TC (2012). Anxiety sensitivity in adolescence and young adulthood: the role of stressful life events, 5httlpr and their interaction. Depression and Anxiety

(2012). Breaking News. Bipolar Disorders, 14(s1), 38-46.

Heijmans BT, Mill J (2012). Commentary: the seven plagues of epigenetic epidemiology. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 41(1), 74-78. Author URL.

Boks MP, de Jong NM, Kas MJ, Vinkers CH, Fernandes C, Kahn RS, Mill J, Ophoff RA (2012). Current status and future prospects for epigenetic psychopharmacology. Epigenetics, 7(1).

Pidsley R, Fernandes C, Viana J, Paya-Cano JL, Liu L, Smith RG, Schalkwyk LC, Mill J (2012). DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice. Mol Brain, 5 Abstract. Author URL.

Unternaehrer E, Luers P, Mill J, Dempster E, Meyer AH, Staehli S, Lieb R, Hellhammer DH, Meinlschmidt G (2012). Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress. TRANSLATIONAL PSYCHIATRY, 2 Author URL.

Pidsley R, Dempster E, Troakes C, Al-Sarraj S, Mill J (2012). Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight. Epigenetics, 7(2), 155-163. Abstract. Author URL.

Bell JT, Tsai P-C, Yang T-P, Pidsley R, Nisbet J, Glass D, Mangino M, Zhai G, Zhang F, Valdes A, et al (2012). Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population. PLOS GENETICS, 8(4), 189-200. Author URL.

Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, et al (2012). Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol, 13(6). Abstract. Author URL.

Ouellet-Morin I, Wong C, Danese A, Pariante CM, Papadopoulos AS, Mill J, Arseneault L (2012). Increased SERT DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant MZ twins. EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY, 3 Author URL.

Mizuno K, Dempster E, Mill J, Giese KP (2012). Long-lasting regulation of hippocampal Bdnf gene transcription after contextual fear conditioning. Genes Brain Behav, 11(6), 651-659. Abstract. Author URL.

Kember RL, Dempster EL, Lee THA, Schalkwyk LC, Mill J, Fernandes C (2012). Maternal separation is associated with strain-specific responses to stress and epigenetic alterations to Nr3c1, Avp, and Nr4a1 in mouse. BRAIN AND BEHAVIOR, 2(4), 455-467. Author URL.

Jeffries AR, Perfect LW, Ledderose J, Schalkwyk LC, Bray NJ, Mill J, Price J (2012). Stochastic choice of allelic expression in human neural stem cells. Stem Cells, 30(9), 1938-1947. Abstract. Author URL.

Wong CCY, Caspi A, Williams B, Houts R, Craig IW, Mill J (2011). A longitudinal twin study of skewed X chromosome-inactivation. PLoS One, 6(3). Abstract. Author URL.

Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, Kalidindi S, Picchioni M, Kravariti E, Toulopoulou T, et al (2011). Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet, 20(24), 4786-4796. Abstract. Author URL.

Wong CCY, Mill J, Fernandes C (2011). Drugs and addiction: an introduction to epigenetics. Addiction, 106(3), 480-489. Abstract. Author URL.

Campbell IC, Mill J, Uher R, Schmidt U (2011). Eating disorders, gene-environment interactions and epigenetics. Neurosci Biobehav Rev, 35(3), 784-793. Abstract. Author URL.

Pidsley R, Mill J (2011). Epigenetic studies of psychosis: current findings, methodological approaches, and implications for postmortem research. Biol Psychiatry, 69(2), 146-156. Abstract. Author URL.

Lunz W, Capettini LSA, Davel APC, Munhoz CD, da Silva JF, Rossoni LV, Lemos VS, Baldo MP, Carneiro-Junior MA, Natali AJ, et al (2011). L-NAME Treatment Enhances Exercise-induced Content of Myocardial Heat Shock Protein 72 (Hsp72) in Rats. Cellular Physiology and Biochemistry, 27(5), 479-486.

Pidsley R, Mill J (2011). Research Highlights: epigenetic changes to serotonin receptor gene expression in schizophrenia and bipolar disorder. Epigenomics, 3(5), 537-538. Author URL.

Engmann O, Hortobágyi T, Pidsley R, Troakes C, Bernstein H-G, Kreutz MR, Mill J, Nikolic M, Giese KP (2011). Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition. Brain, 134(Pt 8), 2408-2421. Abstract. Author URL.

Barclay NL, Eley TC, Mill J, Wong CCY, Zavos HMS, Archer SN, Gregory AM (2011). Sleep quality and diurnal preference in a sample of young adults: Associations with 5HTTLPR, PER3, and CLOCK 3111. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 156(6), 681-690. Abstract.

Barclay NL, Eley TC, Mill J, Wong CCY, Zavos HMS, Archer SN, Gregory AM (2011). Sleep quality and diurnal preference in a sample of young adults: associations with 5HTTLPR, PER3, and CLOCK 3111. Am J Med Genet B Neuropsychiatr Genet, 156B(6), 681-690. Abstract. Author URL.

Mill J (2011). Toward an integrated genetic and epigenetic approach to Alzheimer's disease. Neurobiol Aging, 32(7), 1188-1191. Abstract. Author URL.

Voineagu I, Wang X, Johnston P, Lowe JK, Tian Y, Horvath S, Mill J, Cantor RM, Blencowe BJ, Geschwind DH, et al (2011). Transcriptomic analysis of autistic brain reveals convergent molecular pathology. NATURE, 474(7351), 380-+. Author URL.

Wong CCY, Caspi A, Williams B, Craig IW, Houts R, Ambler A, Moffitt TE, Mill J (2010). A longitudinal study of epigenetic variation in twins. Epigenetics, 5(6), 516-526. Abstract. Author URL.

Meaburn EL, Schalkwyk LC, Mill J (2010). Allele-specific methylation in the human genome: implications for genetic studies of complex disease. Epigenetics, 5(7), 578-582. Abstract. Author URL.

Schalkwyk LC, Meaburn EL, Smith R, Dempster EL, Jeffries AR, Davies MN, Plomin R, Mill J (2010). Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet, 86(2), 196-212. Abstract. Author URL.

Pidsley R, Dempster EL, Mill J (2010). Brain weight in males is correlated with DNA methylation at IGF2. MOLECULAR PSYCHIATRY, 15(9), 880-881. Author URL.

Docherty SJ, Davis OSP, Haworth CMA, Plomin R, Mill J (2010). DNA methylation profiling using bisulfite-based epityping of pooled genomic DNA. Methods, 52(3), 255-258. Abstract. Author URL.

Bouchard L, Rabasa-Lhoret R, Faraj M, Lavoie M-E, Mill J, Perusse L, Vohl M-C (2010). Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction. AMERICAN JOURNAL OF CLINICAL NUTRITION, 91(2), 309-320. Author URL.

Bell CG, Finer S, Lindgren CM, Wilson GA, Rakyan VK, Teschendorff AE, Akan P, Stupka E, Down TA, Prokopenko I, et al (2010). Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus. PLOS ONE, 5(11). Author URL.

Lundstrom S, Haworth CMA, Carlstrom E, Gillberg C, Mill J, Rastam M, Hultman CM, Ronald A, Anckarsater H, Plomin R, et al (2010). Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 51(7), 850-856. Author URL.

Smith RG, Kember RL, Mill J, Fernandes C, Schalkwyk LC, Buxbaum JD, Reichenberg A (2009). Advancing paternal age is associated with deficits in social and exploratory behaviors in the offspring: a mouse model. PLoS One, 4(12). Abstract. Author URL.

Xu X, Mill J, Sun B, Chen C-K, Huang Y-S, Wu Y-Y, Asherson P (2009). Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder. BMC Psychiatry, 9 Abstract. Author URL.

Docherty SJ, Davis OSP, Haworth CMA, Plomin R, Mill J (2009). Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation. Epigenetics Chromatin, 2(1). Abstract. Author URL.

Rutten BPF, Mill J (2009). Epigenetic Mediation of Environmental Influences in Major Psychotic Disorders. SCHIZOPHRENIA BULLETIN, 35(6), 1045-1056. Author URL.

Reichenberg A, Mill J, MacCabe JH (2009). Epigenetics, genomic mutations and cognitive function. Cogn Neuropsychiatry, 14(4-5), 377-390. Abstract. Author URL.

Mill J, Wigg K, Burcescu I, Vetro A, Kiss E, Kapornai K, Tamas Z, Baji I, Gadoros J, Kennedy JL, et al (2009). Mutation Screen and Association Analysis of the Glucocorticoid Receptor Gene [NR3C1] in Childhood-Onset Mood Disorders [COMD]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 150B(6), 866-873. Author URL.

Mill J, Kiss E, Baji I, Kapornai K, Daroczy G, Vetro A, Kennedy J, Kovacs M, Barr C (2008). Association Study of the Estrogen Receptor Alpha Gene (ESR1) and Childhood-Onset Mood Disorders. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 147B(7), 1323-1326. Author URL.

Brookes KJ, Neale B, Xu X, Thapar A, Gill M, Langley K, Hawi Z, Mill J, Taylor E, Franke B, et al (2008). Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth. Am J Med Genet B Neuropsychiatr Genet, 147B(1), 94-99. Abstract. Author URL.

Docherty S, Mill J (2008). Epigenetic mechanisms as mediators of environmental risks for psychiatric disorders. Psychiatry, 7(12), 500-506. Abstract.

Mill J, Tang T, Kaminsky Z, Khare T, Yazdanpanah S, Bouchard L, Jia P, Assadzadeh A, Flanagan J, Schumacher A, et al (2008). Epigenomic profiling reveals DNA-Methylation changes associated with major psychosis. AMERICAN JOURNAL OF HUMAN GENETICS, 82(3), 696-711. Author URL.

Mill J, Petronis A (2008). Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility. J Child Psychol Psychiatry, 49(10), 1020-1030. Abstract. Author URL.

Xu X, Mill J, Zhou K, Brookes K, Chen C-K, Asherson P (2007). Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples. Am J Med Genet B Neuropsychiatr Genet, 144B(1), 83-86. Abstract. Author URL.

Mill J, Petronis A (2007). Molecular studies of major depressive disorder: the epigenetic perspective. Molecular Psychiatry, 12(9), 799-814.

Mill J (2007). Rodent models: Utility for candidate gene studies in human attention-deficit hyperactivity disorder (ADHD). Journal of Neuroscience Methods, 166(2), 294-305.

Brookes K-J, Mill J, Guindalini C, Curran S, Xu X, Knight J, Chen C-K, Huang Y-S, Sethna V, Taylor E, et al (2006). A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch Gen Psychiatry, 63(1), 74-81. Abstract. Author URL.

Mill J, Dempster E, Caspi A, Williams B, Moffitt T, Craig I (2006). Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. Am J Med Genet B Neuropsychiatr Genet, 141B(4), 421-425. Abstract. Author URL.

Mill J, Caspi A, Williams BS, Craig I, Taylor A, Polo-Tomas M, Berridge CW, Poulton R, Moffitt TE (2006). Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder: evidence from 2 birth cohorts. Arch Gen Psychiatry, 63(4), 462-469. Abstract. Author URL.

Dempster EL, Mill J, Craig IW, Collier DA (2006). The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression. BMC Med Genet, 7 Abstract. Author URL.

Mill J, Yazdanpanah S, Gückel E, Ziegler S, Kaminsky Z, Petronis A (2006). Whole genome amplification of sodium bisulfite-treated DNA allows the accurate estimate of methylated cytosine density in limited DNA resources. BioTechniques, 41(5), 603-607. Abstract.

Xu X, Knight J, Brookes K, Mill J, Sham P, Craig I, Taylor E, Asherson P (2005). DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association. Am J Med Genet B Neuropsychiatr Genet, 134B(1), 115-118. Abstract. Author URL.

Xu X, Mill J, Chen C-K, Brookes K, Taylor E, Asherson P (2005). Family-based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: no evidence for association in UK and Taiwanese samples. Am J Med Genet B Neuropsychiatr Genet, 139B(1), 11-13. Abstract. Author URL.

Mill J, Xu X, Ronald A, Curran S, Price T, Knight J, Craig I, Sham P, Plomin R, Asherson P, et al (2005). Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B. Am J Med Genet B Neuropsychiatr Genet, 133B(1), 68-73. Abstract. Author URL.

Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R (2005). Role of genotype in the cycle of violence in maltreated children - Fears of the future in children und young people. ZEITSCHRIFT FUR SOZIOLOGIE DER ERZIEHUNG UND SOZIALISATION, 25(2), 133-145. Author URL.

Mill J, Sagvolden T, Asherson P (2005). Sequence analysis of Drd2, Drd4, and Dat1 in SHR and WKY rat strains. Behav Brain Funct, 1 Abstract. Author URL.

Mill J, Asherson P, Craig I, D'Souza UM (2005). Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1). BMC Genet, 6 Abstract. Author URL.

Craig IW, Mill J, Craig GM, Loat C, Schalkwyk LC (2004). Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes. Eur J Hum Genet, 12(8), 639-646. Abstract. Author URL.

D'Souza UM, Russ C, Tahir E, Mill J, McGuffin P, Asherson PJ, Craig IW (2004). Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene. Biol Psychiatry, 56(9), 691-697. Abstract. Author URL.

Mill J, Richards S, Knight J, Curran S, Taylor E, Asherson P (2004). Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD. Mol Psychiatry, 9(8), 801-810. Abstract. Author URL.

Lowe N, Kirley A, Hawi Z, Sham P, Wickham H, Kratochvil CJ, Smith SD, Lee SY, Levy F, Kent L, et al (2004). Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes. AMERICAN JOURNAL OF HUMAN GENETICS, 74(2), 348-356. Author URL.

Mill J, Curran S, Richards S, Taylor E, Asherson P (2004). Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD. Am J Med Genet B Neuropsychiatr Genet, 125B(1), 38-42. Abstract. Author URL.

Freeman B, Smith N, Curtis C, Huckett L, Mill J, Craig IW (2003). DNA from buccal swabs recruited by mail: evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping. Behav Genet, 33(1), 67-72. Abstract. Author URL.

Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, et al (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301(5631), 386-389. Abstract. Author URL.

Mill J, Fisher N, Curran S, Richards S, Taylor E, Asherson P (2003). Polymorphisms in the dopamine D4 receptor gene and attention-deficit hyperactivity disorder. Neuroreport, 14(11), 1463-1466. Abstract. Author URL.

Chen CK, Chen SL, Mill J, Huang YS, Lin SK, Curran S, Purcell S, Sham P, Asherson P (2003). The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample. MOLECULAR PSYCHIATRY, 8(4), 393-396. Author URL.

Holmes J, Payton A, Barrett J, Harrington R, McGuffin P, Owen M, Ollier W, Worthington J, Gill M, Kirley A, et al (2002). Association of DRD4 in children with ADHD and comorbid conduct problems. AMERICAN JOURNAL OF MEDICAL GENETICS, 114(2), 150-153. Author URL.

Mill J, Curran S, Kent L, Gould A, Huckett L, Richards S, Taylor E, Asherson P (2002). Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder. Am J Med Genet, 114(3), 269-271. Abstract. Author URL.

Mill J, Asherson P, Browes C, D'Souza U, Craig I (2002). Expression of the dopamine transporter gene is regulated by the 3' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet, 114(8), 975-979. Abstract. Author URL.

Mill J, Asherson P, Browes C, D'Souza U, Craig I (2002). Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR:: Evidence from brain and lymphocytes using quantitative RT-PCR. AMERICAN JOURNAL OF MEDICAL GENETICS, 114(8), 975-979. Author URL.

Mill J, Galsworthy MJ, Paya-Cano JL, Sluyter F, Schalkwyk LC, Plomin R, Asherson P (2002). Home-cage activity in heterogeneous stock (HS) mice as a model of baseline activity. Genes Brain Behav, 1(3), 166-173. Abstract. Author URL.

Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297(5582), 851-854. Abstract. Author URL.

Mill JS, Caspi A, McClay J, Sugden K, Purcell S, Asherson P, Craig I, McGuffin P, Braithwaite A, Poulton R, et al (2002). The dopamine D4 receptor and the hyperactivity phenotype: a developmental-epidemiological study. Molecular Psychiatry, 7(4), 383-391. Abstract.

Asherson P, Curran S, Mill J, Taylor E (2001). Association and linkage studies of DAT1, DRD4 and other dopamine system genes in ADHD. BEHAVIOR GENETICS, 31(5), 446-446. Author URL.

Curran S, Mill J, Tahir E, Kent L, Richards S, Gould A, Huckett L, Sharp J, Batten C, Fernando S, et al (2001). Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples. Mol Psychiatry, 6(4), 425-428. Abstract. Author URL.

Mill J, Curran S, Kent L, Richards S, Gould A, Virdee V, Huckett L, Sharp J, Batten C, Fernando S, et al (2001). Attention deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene: evidence of association but no linkage in a UK sample. Mol Psychiatry, 6(4), 440-444. Abstract. Author URL.

Thapar A, Holmes J, Payton A, Barrett J, Harrington R, McGuffm P, Owen M, Ollier W, Gill M, Kirley A, et al (2001). Evidence of association between DRD4 and ADHD with conduct disturbance. BEHAVIOR GENETICS, 31(5), 470-471. Author URL.

Mill J, Galsworthy M, Paya-Cano J, Plomin R, Asherson P (2001). Home-cage activity in heterogeneous stock (HS) mice as a model of human hyperactivity. AMERICAN JOURNAL OF MEDICAL GENETICS, 105(7), 572-572. Author URL.

Curran S, Mill J, Sham P, Rijsdijk F, Marusic K, Taylor E, Asherson P (2001). QTL association analysis of the DRD4 exon 3 VNTR polymorphism in a population sample of children screened with a parent rating scale for ADHD symptoms. Am J Med Genet, 105(4), 387-393. Abstract. Author URL.

Mill J, Caspi A, McClay J, Poulton R, Braithewaite A, Asherson P, Moffitt T (2001). The dopamine D4 receptor (DRD4) gene, behaviour, and psychopathology: a developmental-epidemiological study. AMERICAN JOURNAL OF MEDICAL GENETICS, 105(7), 576-576. Author URL.

Chapters

Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R (2017). Role of Genotype in the Cycle of Violence in Maltreated Children. In (Ed) Biosocial Theories of Crime, Taylor & Francis, 205-208.

Smith R, Mill J (2011). Epigenetics and Chronic Diseases: an Overview. In (Ed) Epigenetic Aspects of Chronic Diseases, Springer London, 1-20.

Mill J, Petronis A (2009). Profiling DNA Methylation from Small Amounts of Genomic DNA Starting Material: Efficient Sodium Bisulfite Conversion and Subsequent Whole-Genome Amplification. In (Ed) Methods in Molecular Biology, Humana Press, 371-391.

Mill J, Petronis A (2009). The relevance of epigenetics to major psychosis. In (Ed) Epigenomics, 411-434. Abstract.

Conferences

Davies J, Franklin A, Commin G, Walker E, Policicchio S, Jeffries A, Burrage J, Chioza B, Liu J, Bray N, et al (2021). CELL-TYPE-SPECIFIC PATTERNS OF DNA METHYLATION IN THE DEVELOPING HUMAN BRAIN. Author URL.

Yap C, Luo C, Vellame DS, Bhattacharya A, Franklin A, Mill J, Gandal M (2021). GENETIC CONTROL OF DECONVOLVED BRAIN CELL-TYPES. Author URL.

Chew EGY, Heng YJ, Lian M, Tandiono M, Dempster E, Policicchio S, Mill J, Reynolds R, Foo JN (2021). Interrogating Parkinson's disease associated mutations at single cell resolution. Author URL.

Shireby G, Hannon E, Commin G, Burrage J, Davies J, Policicchio S, Schalkwyk L, Dempster E, Mill J (2021). LEVERAGING DNA METHYLATION QUANTITATIVE-TRAIT LOCI TO CHARACTERIZE THE RELATIONSHIP BETWEEN METHYLOMIC VARIATION, GENE EXPRESSION, AND PSYCHIATRIC DISEASE. Author URL.

MacCalman A, De Franco E, Jeffries AR, Burrage J, Walker EM, Franklin A, Owens NDL, Hattersley AT, Mill J (2021). Methylomic trajectories in the human pancreas: from fetal development to adulthood. Author URL.

van Dongen J, Hagenbeek FA, Suderman M, Roetman P, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty J, Adams MJ, et al (2020). DNA methylation signatures of a broad spectrum of aggressive behavior: a meta-analysis of epigenome-wide studies across the lifespan. Author URL.

MacCalman A, De Franco E, Jeffries AR, Hannon EJ, Davies J, Burrage J, Morgan NG, Hattersley AT, Mill J (2020). Regulatory genomic variation in the developing human pancreas. Author URL.

Dbeis R, Rist C, Daniels I, Smart N, Mill J (2017). DNA METHYLATION IN RECTAL CANCER: CLINICAL IMPLICATIONS. Author URL.

Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). LONGITUDINAL EPIGENETIC ANALYSIS OF CLOZAPINE USE IN TREATMENT-RESISTANT SCHIZOPHRENIA. Author URL.

Knight B, Taylor MT, Mill J (2017). The Peninsula Pre/Perinatal Twins Research Bank (PTRB): Facilitating research into epigenetic and transcriptional variation in twins. Author URL.

Lunnon K, Smith R, Hannon E, Smith A, Schalkwyk LC, Haroutunian V, Mill J (2015). O3‐05‐01: Systems‐level evidence for epigenetic dysfunction in Alzheimer's disease.

Lunnon K, Smith R, Hannon E, Volta M, Troakes C, Haroutunian V, Katsel P, Al‐Sarraj S, Lovestone S, Schalkwyk L, et al (2014). O3‐04‐03: CROSS‐TISSUE METHYLOMIC PROFILING IN ALZHEIMER'S DISEASE.

Ruggeri B, Nymberg C, Vuoksimaa E, Lourdusamy A, Wong CP, Carvalho FM, Jia T, Cattrell A, Macare C, Mill J, et al (2014). The Role of DNA Methylation in the Aetiology of Alcohol Dependence. Author URL.

Alkelai A, Baum A, Carless M, Crowley J, DasBanerjee T, Dempster E, Docherty S, Hare E, Galsworthy MJ, Grover D, et al (2008). The XVth World Congress of Psychiatric Genetics, October 7-11, 2007: Rapporteur summaries of oral presentations. Abstract.

Dempster EL, Mill JS, Murray R, Collier DA (2004). Expression analysis of five schizophrenia candidate genes in post-mortem cerebellum samples using quantitative real time RT-PCR. Author URL.

Mill J, Browes C, Craig I, D'Souza U, Asherson P (2002). Expression of the dopamine transporter gene is mediated by genotype: Evidence from brain and lymphocytes using quantitative RT-PCR. Author URL.

External Engagement and Impact

Awards

2001 Young Investigator Award, World Congress of Psychiatric Genetics (St. Louis)

2003 Young Investigator Award, World Congress of Psychiatric Genetics (Quebec City)

2005 Young Investigator Award, World Congress of Psychiatric Genetics (Boston)

2005 Canadian Institutes of Health Research Postdoctoral Fellowship (Canada)

2007 Young Investigator Award, World Congress of Psychiatric Genetics (New York)

2007 NARSAD Young Investigator Award

2008 British Medical Association (BMA) Margaret Temple Award

2009 King’s Award – Young Researcher of the Year across King’s College London

2017 International Society of Psychiatric Genetics, Theodore Reich Prize

2016 Distinguished Investigator Award, Brain & Behavior Research Foundation

Committee/panel activities

Member of the Department of Health’s Emerging Science and Bioethics Advisory Committee (ESBAC).

MRC Neuroscience and Mental Health Board (from April 2021)

Alzheimer’s Society, Grant Advisory Board (from 2017)

Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), International Advisory Board (from 2016)

Autistica, Science Review Panel (from 2014)

Alzheimer’s Research UK South-West Network Committee (from 2014)

Wellcome Trust Epigenomics of Common Diseases Meeting, Organizing Committee (from 2020)

Editorial responsibilities

Associate Editor, BMC Psychiatry

Editorial Board, American Journal of Medical Genetics, Neuropsychiatric Genetics

Editorial Advisory Board, Journal of Child Psychology & Psychiatry

Associate Editor, Frontiers in Child and Neurodevelopmental Psychiatry

Media Coverage

2012 New Scientist. 21st February. Linking genes, cerebellums and schizophrenia

2011 BBC Radio 4. 17th, 24th, and 31st August. The First 1000 Days: A Legacy for Life

2010 BBC Radio 4 Frontiers. Epigenetics

2010 New Scientist. 3rd November. Genes marked by stress make grandchildren mentally ill

2010 Daily Mail. 30th March. Don't blame your genes…change them!

2008 New Scientist. 9th July.Rewriting Darwin: The New Non-Genetic Inheritance

2008 Sunday Times. 20th July. How your behaviour can change your children's DNA

Supervision / Group

Postdoctoral researchers

Postgraduate researchers

Szi Kay Leung
Simeng Lin
Ailsa MacCalman
Emma Walker

Research Technicians

Alumni

Marta De Oliveira Ferreira Das Neves Nabais
Katie Lunnon
Ruth Pidsley
Dorothea Seiler Vellame
Chloe Wong

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