The 36-Hour Fast in a Pill With Biomimetic Supplements

  |   EP134   |   65 mins.

Chris Rhodes

On this episode of Mind Body Peak Performance, Nick is joined by and Dr. Chris Rhodes, Founder and CEO of Mimio Health. They explore biomimetic supplementation and its ability to replicate fasting benefits.

From the science behind lifespan extension to the potential of biomimetic supplements, they delve into metabolic health, fasting, and the future of regenerative states. Stay tuned for insights on longevity, fasting mimetic molecules, and the impact of validated supplements.

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Episode Highlights

There's a 100,000 studies on fasting, showing it has these profound effects on both health span and lifespan. And the interesting thing is that it does all of that but without actually adding anything into the system. Click To TweetYou could really activate these beneficial fasting pathways even during a meal and prevent a lot of these metabolic disruptions, dietary inflammation, and brain fog effects. Click To TweetIt has almost like CBD-style effects that helps promote recovery, promote mood enhancement, but then also relieve everyday aches and pains of getting older or if you have some kind of muscle soreness or joint soreness. Click To Tweet

About Dr. Chris Rhodes

Mimio Health is a nutritechnology company creating first-of-their-kind biomimetic supplements designed from human biology to recreate the body’s innate regenerative systems. Now available to the public, their biomimetic formula (Mimio) was discovered by founder Dr. Chris Rhodes while obtaining his Ph.D. in Nutritional Biochemistry at UC Davis.

Designed to study and decode the longevity-enhancing effects of fasting, his research found that there are unique molecules produced in the human body that are only elevated during a 36-hour fast. By taking these “fasting metabolites” and giving them back to our cells, his team could mimic the beneficial effects of fasting and nearly double the lifespan of model organisms. All without any need to fast.

Top Things You’ll Learn From Dr. Chris Rhodes

  • Introduction to biomimetic supplementation and fasting mimicry
    • The relationship between fasting and biomimetic supplementation
    • Biomimetic supplementation mimics the benefits of fasting without the inconvenience
    • How fasting or fasting mimicking diets can translate to a 96% extended lifespan
  • Benefits and practices of fasting and nutrient optimization
    • Dr. Rhodes’ personal knowledge and experience in fasting, paleo, and intermittent fasting
    • Maximizing nutrients with minimal caloric density for health benefits
    • Discussion on the potential future biomimicry products
  • Mimio’s formulation and bioactive ingredients
    • Formulation development and safety testing
    • Over 300 significant differences between baseline and fasting states
    • The combined roles of palmitoyl ethanolamide, oleoylethanolamide, spermidine, and nicotinamide
    • No specified need for cycling the supplement
    • Aiding in weaning individuals off GLP-1 agonists
  • Regenerative states and longevity
    • Potential benefits of different fasting durations, exercise, meditation, and cold exposure therapy
    • Safety concerns regarding the supplementation of fasting-related molecules
    • Importance of building muscle mass responsibly for longevity
    • Recommendations for low-impact strength training when fasted
  • The importance of metabolic health in promoting longevity
    • The impact of metabolic health on preventing frailty and age-related conditions
    • The connection between metabolic health and the rate of aging
    • Focusing on metabolic health for better aging and quality of life
    • Discussion on fasting as a subtractive intervention and its benefit
    • Biochemical effects of fasting on plasma and identification of fasting-induced molecules

Resources Mentioned

  • Supplement: Mimio Health’s Biomimetic Supplement (code URBAN saves 15%)
  • Teacher: Amy Poehler
  • Teacher: Tina Fey

Episode Transcript

Click here

Nick Urban [00:00:05]:

Let’s face it. Fasting sucks. What if there was a pill that you could take that would mimic and replicate most of the benefits you get when undergoing a 36 hour fast. Those same benefits without the hassle and the inconvenience and the deprivation. Or imagine if that same pill amplified the benefits you get during that fast. That’s exactly what we’re covering today in this episode With our guest who is pioneering the field of biomimetic supplementation, basically taking particular ingredients that replicate the internal effects we get from activities that most of us know are healthy, but don’t exactly enjoy. Hi. I’m Nick Urban, host of the Mindbody Peak Performance podcast.

Nick Urban [00:00:57]:

Thanks for tuning in today. And in this episode, we’re going to cover The concept of biomimicry, what it is, why it’s so important, and what you should know in order to harness the full power of it. We’ll also talk about fasting and different ways you can amplify your fasts so that you get better results in shorter time and with less hassle. Another key topic we’ll cover is the importance of not just taking research backed supplements, But choosing products that have actually validated the final product because oftentimes, when you add different ingredients together, They work better, a supplement synergy. But sometimes, if you’re combining too many and you haven’t done your due diligence, That combination can actually detract from each of them and lead to a net negative. And in this episode, you’ll also learn about Four ingredients that aren’t nearly as popular as they should be and how a company called Mimio has cracked the code on a simple yet comprehensive fasting mimetic product. Our guest this week is doctor Chris Rhodes. You’ll hear more about his background, Who he is and how he got involved in all this in the episode itself, but he is the one who came up with the biomimetic formula for his company called Mimio Health.

Nick Urban [00:02:19]:

They are a nutri technology company creating the first of kind biomimetic supplement Designed from human biology to recreate the body’s innate regenerative systems. Doctor Chris Rhodes has a PhD in nutritional biochemistry from UC Davis, and he’s now sharing This special formula with the public and educating on how this has been able to transform so many lives. And if this kind of thing piques your interest, Stay tuned because doctor Chris Rhodes mentioned to me that they are not only looking at fasting mimetics, but also exercise mimetics and all kinds of other biomimicry products. For all the resources we discussed, you can find those at mindbodypeak.com/one thirty four. You can also use the code urban on the Mimio Health website, and that’ll save you on your orders should you choose to try it yourself. If you find this episode helpful, I’d appreciate you sharing with a friend or going on to wherever you’re listening to this, and leave a rating and review. That’s how this show gets found and how I continue bringing you thought provoking guests like doctor Chris Rhodes. Without further ado, sit back, relax, And enjoy this episode with Mimio Health and doctor Chris Rhodes.

Nick Urban [00:03:39]:

Doctor Chris Rhodes, welcome to Mindbody Peak Performance.

Dr. Chris Rhodes [00:03:43]:

Thanks, Nick. I’m really happy to be here.

Nick Urban [00:03:45]:

So I just met you yesterday, and we had a fun conversation. And I’d like to start off today with Your explanation of what biomimicry is and how you are able to extend lifespan by 96%.

Dr. Chris Rhodes [00:04:00]:

Yeah. Absolutely. It’s a big question. So first off, biomimicry is essentially studying natural systems, and then finding ways to kind of decode and recreate them so that you can find these solutions to our modern day problems that Might have already been solved by nature. Right? So the way that we use it at Mimio is essentially we want to study human biology, understand what really makes us tick, how our body has responded and evolved to have these regenerative systems and pathways that are already inside of it that it can kind of turn on and off when it wants to and when it needs to, and then find a way to unlock those things and put them on demand. And so how we were able to do this and how we were able to, you know, get this really interesting doubling of lifespan was by studying what happens in the human body during a fast. So fasting is really interesting to study as, like, a biomimetic state because it’s one of the few, it’s one of the few interventions that we know of that can reliably extend the lifespan in model organisms. And beyond that, it can also help to treat, prevent, or delay most major disease diseases.

Dr. Chris Rhodes [00:05:17]:

There’s, you know, a 100,000 studies on fasting seeing showing it has these really profound effects on both health span and lifespan. And the interesting thing about that is that it does all of that, But without actually adding anything into the system. Right? So it’s not like, you know, you’re taking this superfood or this wonder drug, But fasting is somehow activating this innate longevity bio program that we already have inside of us. So we at Mimio wanted to tease out what is this bioprogram, what’s happening in the human body that’s activating these regenerative pathways And optimizing our cellular functions specifically for survival and longevity, and then how do we hack into that and harness it? And long story short, we found that there were these unique sets of molecules that were elevated in the body during a fast that are the ones that are responsible for activating this longevity bio program. And when we give them back to people, and organisms as a supplement, we can recreate the benefits of fasting, but just through supplementation. So that’s essentially how we were able to Extend lifespan by 96% was through the recreation of this, you know, fasting bio program.

Nick Urban [00:06:37]:

That’s fascinating, and we’ll talk about more on that in a second and some of the other biomimicry, like, optimal States that you guys are working on recreating and what the potential is there. But before we do, what are the essentials or nonnegotiables you’ve done so far today for your health, Your performance and your bioharmony.

Dr. Chris Rhodes [00:06:57]:

Yeah. That’s a great question. So, I mean, obviously, for me, it all comes down to fasting. Right? You know, I’m a big believer in it. I’ve, you know, read through a lot of those 100,000 studies that are out there around fasting. So I really think that it’s one of the best ways to help promote health span, promote lifespan. That’s actually one of the reasons why I started researching it. I read a review paper around fasting, saw that it had these profound impacts on health, and actually started I was, You know, I was an intern, doing a fellowship at Stanford at the time and had a really supportive lab that was doing a lot of immunology research.

Dr. Chris Rhodes [00:07:35]:

So I was like, alright. I’m gonna fast. I’m gonna take my own blood. I’m gonna look at my own cellular function, and I’m gonna see what happens. And, basically, what I saw Was in my own plasma, my cells became way more functional. They were a lot more resistant Cellular stress, they had better survivability. They had better longevity. They were less reactive to autoimmune stimuli.

Dr. Chris Rhodes [00:07:59]:

And that was just a really big breakthrough for me to be able to see, like, I did something, and it immediately affected My health, like and I’m already, you know, a young a young healthy person. So this is taking me from already being that, you know, that baseline level of healthy to then that next level of really, like, boosted cellular optimization. So that’s kind of, at this point, my my nonnegotiable is that I fast. I do, like, 1 meal a day. And then, you know, generally speaking, because I also got my PhD in nutritional biochemistry, I know all the ins and outs of the food system and what we should and should not be eating, which is a blessing and a curse. You know? But I generally try to keep, more towards, like, a paleo diet. And I say that as, like, a very A very useful term to describe what I’m doing, but not really like a a hard and fast rule kind of thing. I generally try to like a lot lots of vegetables, lots of lean proteins, not a lot of processed foods or sugars or anything like that.

Dr. Chris Rhodes [00:09:03]:

And that’s more or less what I eat on a day to basis not because I think that, you know, oh, it’s how our ancestors eat, and therefore, that’s how we should eat, but it just fits really well into my overarching philosophy, which is more like nutrition maximalism where it’s like get the most nutrients and, you know, bioactives And micronutrients, vitamins, and minerals that you can with the lowest amount of caloric density, and that’s kind of the the right path forward.

Nick Urban [00:09:33]:

Interesting. Yeah. And fasting is one of the those, like, rare interventions where it’s not additive. In In fact, it’s subtractive. Like, you take out the food, and you notice, like, health benefits.

Dr. Chris Rhodes [00:09:45]:

Yeah. I mean and I think that that’s that goes to show a couple things. Like, number 1, obviously, this goes back to the whole biomimicry thing. Right? What happens in fasting in the body is this evolutionarily conserved process. Because when you think about what’s really going on from a survival perspective, when you’re eating constantly, your body kind of, you know, becomes lazy. It, like, runs dirty. Right? It has all of this energy. It has all these nutrients, so it’s not gonna Pay all that much attention to, like, oh, am I making too many proteins? Is this, like, mitochondria not running, like, super optimally? If if a cell breaks down, if it gets damaged, it’s fine.

Dr. Chris Rhodes [00:10:25]:

I have all this energy. I can just make more. But then all of a sudden in a fasting state, right, All those all those extra nutrients are gone, so that sends a signal to your cells that holistically changes their function. So If, you know, if something goes wrong, they don’t have the energy to make a new cell, so they have to kind of turn on all of these metabolic efficiency pathways that are essentially, know, doing cellular recycling, breaking down dysfunctional organelles, or repairing them, you know, like, really optimizing cellular maintenance so that it can protect the cells that are there, and, really help them live as long as possible with as little fuel as possible, and, ultimately, that’s kind of what longevity is.

Nick Urban [00:11:12]:

Yeah. You mentioned that you eat 1 meal a day, OMAD. And are you also doing any other forms of fasting, like 24 hour Fasting or multiday fasting, water fasting, dry fasting, there’s so many different forms.

Dr. Chris Rhodes [00:11:26]:

Yeah. There are so many different forms and for, you know, so many different acronyms So none like letters and numbers involved. But, yeah, OMAD is OMAD is my favorite. When I originally started doing fasting, It was alternate day fasting, and that was based on, you know, the literature results for the best lifespan tension. That’s typically where you see in model organisms. You can have anywhere between, you know, 30% lifespan extension all the way up to 80% lifespan extension Without the reduction of calories, and that was something that was really attractive to me. Right? I was like, great. I don’t have to actually eat any less.

Dr. Chris Rhodes [00:12:02]:

It’s just all a matter of timing. But the alternate day fasting lifestyle was not super conducive to, you know, being a integrated member of society that, like, has friends and coworkers and people that you like to hang out with or, like, you know, family dinners that you like attending. So at one point or another, I was, like, I was pretty into it. My sister, who’s also my cofounder, at Mimio, she talks to me. It’s like, sure. Like, you’re doing this. Right? Like, You’re you’re getting all these great longevity benefits. You can see it in yourself.

Dr. Chris Rhodes [00:12:34]:

That’s great. But what’s the point of living longer if you have to live less? Right? And that was kind of like my wake up call. I also then got into a relationship, and my partner was very much like, no. You’re gonna have dinner with me. I’m not like, No one no one wants to see me there just like, okay. I’m gonna hold my glass of water, and I’m gonna stare directly at you while you eat, and then I’ll just carry on the conversation. So One meal a day ended up being the thing that kind of worked the best for my lifestyle. And it’s kind of the minimum amount of fasting thing that I would really recommend if you’re looking to truly get into, like, the the longer term, like, benefits of fasting, because it takes around, like, 20 to 24 hours for your body to really, deplete your glycogen stores and Actually start entering into a full fledged fasting metabolism and ketosis and things like that.

Dr. Chris Rhodes [00:13:30]:

So, like, shorter term fast, like 16:8, they can be really good or kind of condensing your eating window, getting some effortless weight loss, and, like, it’s been shown to actually move cardio Protective markers around, specifically around metabolic health and cardiovascular health. But outside of that, There’s a lot of benefits that people think they’re getting with the shorter term fasts like autophagy or, like, you know, immune cell regeneration that they’re not Actually getting until much later stages of fasting, like the 36 hours, the 48 hours, the 72 hours.

Nick Urban [00:14:05]:

I tried 1 meal a day a couple years ago, and I did it for a while. Ultimately, I stopped because I realized that if I was in a social setting where I couldn’t get enough, like nutrient dense food or something, then I would panic a little bit and be like, okay. Like, this is my 1 meal. I really have to be fully optimized for this meal. I have to get a ton of calories, ton of macros, and I became a little bit orthorexic around it. So I ultimately stopped, but it was very convenient when it was working for me. Are you doing anything to get other, Like, essential nutrients outside of the eating window?

Dr. Chris Rhodes [00:14:38]:

Yeah. For me, it’s not that big of an issue because of the whole nutrition thing. So it’s like, my typical my typical dinner is kinda gonna be, like, chicken in some form or another and then just A huge amount of of vegetables because that’s just how I really like to eat. I just like eating as much as I possibly can to kind of, like, You know, fill up throughout the rest of the, you know, throughout the rest of the the fasting period. So, yeah, like, a little bit of, like, orthorexia. I think it just kind of comes with the come with the lifestyle. But, yeah, it’s gonna be it’s gonna be vegetables that are, like, again, like, very calorically, like, minimal, but very, like, volume intensive. So, like, Things like cabbage or zucchini or cauliflower or, like, you know, carrots and broccoli and, like, and things like that.

Dr. Chris Rhodes [00:15:28]:

I’m a big fan of a, you know, a zucchini noodle or a cauliflower rice kind of situation. And that’s That’s been, like, more than sufficient to keep me, like, full focus, but then also, like, well nourished in terms of micronutrients. And I don’t really take much outside of actual, like, bioactives from, From different sources, and, of course, the actual Mimio formulation, which is all the the the biomimetic bioactives.

Nick Urban [00:15:58]:

So let’s go on and talk about that now because One meal a day, extended fasting, there might be some good data around it, but a lot of people aren’t gonna wanna implement that into their lifestyles to, like, Decide they’re gonna go multiple days without food or to get yelled at by their partner for just staring at them blankly while they’re sitting there with their empty plate. So tell me about Mimio and your approach.

Dr. Chris Rhodes [00:16:19]:

Mimio is essentially, you know, the world’s 1st fasting mimetic Supplement that was actually designed from clinical fasting research that I was doing as part of my PhD at UC Davis. So, essentially, where the formulation came from was, we took, 20 people, 10 men, 10 women, Had them come in and fast for 36 hours and did a before and after. And while they were doing the 36 hours of fasting, I was also having them do, blood glucose monitoring for compliance testing, but this was before CGMs were really popular. So they were doing, like, finger prick Analysis every, like, 2 hours. So I was everybody’s favorite said he was like, hey, don’t eat for a whole day, and while you’re doing that, just, like, you know, Constantly poke yourself and, like, read your blood. Thanks. But what we found was really, really interesting. It was very similar to what I saw in my own cells when I first started doing the experiments with fasting, everybody became very functionally enhanced.

Dr. Chris Rhodes [00:17:23]:

So their plasma became more inflammatory. It became more antioxidant, more, cellular protective, and then more cardio protective as well. And then, of course, their metabolic readings were way more in line and, like, not nearly as crazy as they were before. So that’s really interesting for us. Right? Like, if you can take already young functional people and make them even more functional through fasting In, like, a single intervention over the course of one day, that’s pretty significant, especially in the nutrition world. And so we wanted to find out, alright, what’s the difference between One state, the baseline state, and the fasting state that could be causing these differences. So we did what’s called comprehensive metabolomics where we looked at all of the small molecule components of the plasma. And what we found was that there were over 300 significant between the baseline state and the fasted state that could kind of be, you know, responsible for these effects that we were seeing.

Dr. Chris Rhodes [00:18:23]:

And of that list of 300, You know, there there was around, you know, 50 or so that had, some kind of literature result of having bioactivity, whether that’s in Increasing autophagy or enhancing anti inflammatory activity or antioxidant capacity, what have you. So from that list, Then we screen through those molecules to find ones that on their own could recreate these beneficial effects that we were seeing in the cells. And eventually, we narrowed our list down to this 4, this combination of 4 of these molecules that we identified worked synergistically be together and could recreate these beneficial effects of fasting. So those same anti inflammatory, antioxidant, and cardioprotective benefits, We could induce, just through supplementation with those molecules. And then, of course, because we were really interested in the whole longevity and lifespan aspect, We also did a C. Elegans, C. Elegans lifespan analysis. And what we found was that when we supplemented The Mimio formulation, these 4, you know, fasting metabolites into, the c elegans, the little nematode worms, we could extend their life and by 96% just through supplementation.

Dr. Chris Rhodes [00:19:40]:

No fasting required. No caloric restriction required, just through supplementation. And that was kind of, like, you know, our big blockbuster discovery because to, like, really put it in perspective for people if they already know about Some of the popular antiaging drugs like rapamycin or metformin, like in that same c elegans model, Rapamycin extends lifespan by 19%. Metformin extends lifespan by 36%. And then, yeah, Mimio is extending lifespan by 96%, and it’s this combination of natural human molecules, jewels, that are really, really safe, really, really effective, don’t have any crazy side effects. It’s it’s really it’s really phenomenal.

Nick Urban [00:20:24]:

Yeah. It’s very impressive. What is the lifespan extension of just fasting, normal fasting for the C. Elegans?

Dr. Chris Rhodes [00:20:31]:

Yeah. Great question. We actually compared that as well. And what we found was that, when you do kind of like, It’s like an alternate day fasting cycle with C. Elegans, which is 12 hours on, 12 hours off. You get a 51% Lifespan extension. So, again, like, these things these things are, you know, even pushing that beyond, what you can achieve from actual fasting. And then that has to do with, you know, the fact that these molecules are activating these complementary, fasting pathways, but without any of the negative Drawbacks that can come along with severe core restriction that can come with fasting.

Nick Urban [00:21:10]:

Well, I certainly wanna dig into your formula that is the magic sauce of all this. But before we do, I wanna know how people are using this and what kind of results you’re seeing in the general population.

Dr. Chris Rhodes [00:21:23]:

Yeah. We’ve had some really great results from our customers. We hear all the time that, you know, there’s there’s great effects on boosting energy, seeing cognition, some pain relief elements to it as well. Like, we’re really working underneath the underneath the surface at cellular level to kind of optimize cellular functionality activate these, beneficial fasting pathways on demand. And so what you really get from that from customers is this big, just, you know, optimization of of function. People have told us it’s Kind of kind of like pure human awesomeness is one of my favorite quotes where it’s like, I don’t feel, like, high. I don’t feel buzzed. I just kind of feel, like, at Peace with the universe, which makes sense because the actual ingredients that are in Mimio have over a 100 different Clinical studies behind them showing that they have a lot of different effects across a lot of different, like, indications and use cases.

Dr. Chris Rhodes [00:22:25]:

So the we kind of got lucky in a certain extent. Like, these things don’t just operate at the cellular level, but then they also have these holistic full body benefits And, like, you know, day to day benefits that you can feel as well.

Nick Urban [00:22:38]:

Yeah. Exactly. And I love with a lot of these ingredients, they’re Looked out for, like, their longevity uses, and that might be the primary indication for use. But then again, some of them have, like, cognition Enhancing effects or energy boosting effects and, like, all kinds of other things that, like, if you take a formula that includes a smart combination of them, You can enjoy all kinds of things simultaneously.

Dr. Chris Rhodes [00:22:58]:

Yeah. Exactly. And what we really see from our customers too is, you know, this is beyond just a longevity supplement. You know, we do you can use it as a like a fasting mimetic. Right? We’ve shown in our pilot clinical study that when you take this with food, you can prevent a lot of these negative effects of eating that happen. So basically, what we did for that study was we had people come in, Eat a standardized breakfast alongside a placebo control, tested their plasma functionalities like we had in the fasting study, And then had them come back after a washout period, eat that same standardized breakfast, but then with supplementation with Nimeo, and track their plasma functionalities throughout, like, the postprandial, post eating time course. What we found was that when people ate the standardized breakfast As with the placebo control, there is a big loss of plasma functionality, which is super typical. Right? That’s called the post prandial response.

Dr. Chris Rhodes [00:23:55]:

You have all of this, you know, foreign material that’s coming into the system from the food, throwing things into metabolic chaos, activating immune so their plasma became more pro inflammatory, less antioxidant, less cardio protective. But When they had that same meal, but with supplementation with Mimio, we saw that we could not only prevent all of that loss of function, but then actually add gains of function on top of that that mimicked what we saw during a 36 hour fast. So You could really activate these beneficial fasting pathways even during a meal and prevent a lot of these metabolic Disruptions, dietary inflammation, you know, brain fog effects that were happening from eating that meal. So that’s kind of a big major use case us is even just beyond the day to day longevity, aspects of it. You can also use it as a metabolic enhancement product. And then, of course, also, because we’re mimicking a 36 hour fast like what we were talking about before, you have a lot of people who are doing more of the 168 Style of fasting, that’s the most popular version of fasting that there is. And people think that they’re getting all of these benefits like autophagy and immune cell regeneration from these longer fasts, but really they’re not. And so Mimio is great because it was designed to recreate the effects of a 36 hour fast.

Dr. Chris Rhodes [00:25:20]:

So you can use it as a fasting enhancer, you know, take it in the morning, without any food and help to really, like, supercharge the benefits of the Shorter fast that you’re doing and get, you know, these benefits of longer term fasting, the elevation of these great fasting metabolites that you wouldn’t ordinarily experience. And then there’s an appetite suppression component to that as well, which is great. We’ve heard from a lot of that they can actually fast for longer than they’ve ever been able to before, thanks to Vimeo.

Nick Urban [00:25:51]:

That’s really cool. I love it. It has a dual use. You can either use it as a replacement for fasting, or you can also combine it with a fast to pretty much amplify the benefits. So if I was doing a 24 hour fast and I was skipping dinner And then alright. Say, yeah, I start at the end of dinner and then I go 24 hours till dinner the next day, I can fast after dinner, obviously. And then The next morning, I could take Vimeo, and I could get stronger effects, wake up fasted, take it, suppress my appetite a bit, Make the fasting till dinner easier and enjoy more effects, better effects from my fast at the same time. Are there any wrong ways to use it, and how fast do people start noticing an impact?

Dr. Chris Rhodes [00:26:31]:

Yeah. I wouldn’t say that there is particularly a wrong way to use it. You know, you can use it with a meal. You can use it without a meal. I would It also depends on how quickly or sorry. What who who’s taking it, what their biology is, how quickly they’ll actually experience benefits. There are some people who are very sensitive to, the OEA or the PEA that are in the that are in the formulation. PEA specifically is part of the endocannabinoid system, and it helps to stimulate the secretion of anandamide, which is one of the body’s bliss molecules.

Dr. Chris Rhodes [00:27:08]:

And so it has almost like CBD style effects that helps, you know, promote recovery, promote mood enhancement, But then also, like, relieve kind of everyday aches and pains of getting older or if you have some kind of, you know, like, muscle soreness or joint soreness, things like that. So that effect can be pretty acute, especially if you’re already in some kind of pain. Otherwise, I would kind of, put it on the realm of if you take Buprofen, when you’re not actually in pain, like, are you gonna notice the effect? But a big one that people might notice immediately is ole oil, ethanolamide. And that is OEA, which is the hunger suppression component. And that’s involved in the gut brain access where it actually stimulates and stimulates the production of GLP one. So it’s kind of like your body’s natural, to a certain degree. And that’s something that we hear a lot from customers that they have, like, very big appetite suppression effects from taking the the OEA in the formulation. And then outside of those, you know, 2 things, the kind of, you know, mood and energy and appetite suppression effects from those 2 molecules.

Dr. Chris Rhodes [00:28:20]:

Like, really benefit should start appearing more towards, like, you know, the 1 month time point, the 2 month Time point when you look at the clinical, evidence of what’s out there, and it’s like it’s very robust. Like I said, over a 100 different clinical studies with these individual molecules. 60 days is usually where you get the best, where you get the best significance in before and after readings. That’s like the most studied time point. So I would say that, you know, you could feel benefits right away, or it could take, you know, anywhere between 1 to 2 months to really, You know, be able to track it through biologically and see how Mimio has improved your underlying health, but also your day to day function.

Nick Urban [00:29:03]:

Okay. And since this is a biomimetic, I’m guessing that you don’t need to cycle it, but do you?

Dr. Chris Rhodes [00:29:10]:

Yeah. You know, there’s it’s really a down to personal preference. There’s benefits to cycling Always, but I don’t think that you really need to. Like, the best example that I have of, of the benefits of not cycling Is that lifespan extension analysis. Right? Like, you see elegans were, constantly on Mimio. They didn’t take a day off. They were just always there. And with any lifespan intervention, the longer and more consistent that you’re on it, the more effective that it’s gonna be.

Dr. Chris Rhodes [00:29:44]:

I think that the best way to think about it is is essentially like sunscreen. Right? Like, if you wear sunscreen every day, the earlier you start, you know, eventually, you’re just gonna, like, Diverge and become, you know, like a lot. Oh, like, you’re gonna get much more benefits over time with consistent use rather than like, oh, I’ll start using it when I’m And, you know, we’ll we’ll take it from there.

Nick Urban [00:30:06]:

Okay. So you’ve already mentioned a couple of ingredients. Let’s do a run through of of what is in your formula, and I’m also curious about how you settle on the dosages for each.

Dr. Chris Rhodes [00:30:17]:

Absolutely. So, yeah, we talked about palmitoyl ethanolamide, the endocannabinoid that helps to, like, relieve pain, enhance mood, your body’s natural CBD, essentially. And then also oleoylethanolamide, always fun to say, the tongue twister of the bunch. And that’s involved in the gut brain axis where it helps, Like, really systemically, regulate metabolism, especially on a cellular level, promotes fat Specific breakdown helps to suppress appetite. It’s a AMP kinase stimulator. It’s a PPAR alpha stimulator. So, like, really, like, big big master metabolic regulator. Then we also have spermidine, which is, like a very popular longevity molecule.

Dr. Chris Rhodes [00:31:00]:

It’s a breakdown product of arginine, and essentially is best known for enhancing autophagy in cells. It has a lot of clinical evidence as well of, like, having these metabolic control aspects, and being able to actually Prevent diet induced obesity in mice while controlling, like, glucose levels and insulin levels. So very, very, very, very interesting molecule, and then also lots of clinical evidence, or at least early evidence that shows that it has a great effect on cognitive especially with people with dementia and cognitive decline and being able to, like, enhance CRAD scores, memory, mood, and focus. The 4th ingredient that we have in Mimio is Nicotinamide, and we use that a little bit differently than everybody else Does. So a lot of other forms that you see out there are, like, Nicotinamide Riboside, Nicotinamide Mononucleotide, and those are typically used as NAD plus precursors. And NAD plus from a cellular perspective is essentially one of the ways that cells sense the, energy levels within a cell. So if you have a lot of NAD plus, that’s a cellular signal That there’s not a lot of energy around, and so that then goes on to activate this cascade of pathways that are associated with fasting. And that’s why you see a lot of great health span extension that happens through, like, NR and NMN supplementation.

Dr. Chris Rhodes [00:32:31]:

So Nicotinamide is kind of the precursor to all of those molecules. It’s where, like, it gets converted into Nicotinamide Riboside, which then gets converted into NMN, which then gets Convert into NAD and then that kind of that cycle all, like, repeats itself. And then the end product of that, The quote, unquote waste product of that is 1 methyl Nicotinamide. And 1 methyl Nicotinamide is actually what we identified in the fasting study To be upregulated during a fast works synergistically with all of these other molecules. And we use Nicotinamide as a precursor For 1 methyl Nicotinamide, and we showed in our, you know, pilot clinical study, our dosing and p k analysis, That when you take Nicotinamide, there’s a big increase in 1 methyl Nicotinamide levels in circulation. And, you know, it still has all these great synergies and effects with Dyspermidine, the PEA, and the OEA. And so there’s, like, you know, been for a long time, one methylenegotinimide has not Really been on people’s radars, because, you know, it’s been thought of to be just a kind of a waste product. But now there’s a lot of good emerging evidence Showing that 1 methyl Nicotinamide actually has these really profound immune regulatory effects, cardioprotective effects, and also, enhanced exercise performance and recovery effects as well.

Dr. Chris Rhodes [00:33:53]:

So lots of lots of cool research around the and something interesting that we’re doing that really, like, no one else in this space is focusing on.

Nick Urban [00:34:02]:

So why not just use 1 methyl Nicotinamide in the 1st place instead of going down the other route.

Dr. Chris Rhodes [00:34:08]:

Yeah. It’s a good question. We would really like to use 1 methyl Nicotinamide, but, unfortunately, there’s just regulations around It, so there was a company back in the day that filed an IND on one methyl Nicotinamide because they wanted to use it, for like, as a cardiovascular disease drug, essentially, and that didn’t end up going through. But the way that the regulations work In in the US is that if anything at any point in time has ever had an IND filing on it, then it can never ever again be used as a A dietary supplement. So the only way to get 1 methyl Nicotinamide is to use Nicotinamide.

Nick Urban [00:34:48]:

And what does IND stand for?

Dr. Chris Rhodes [00:34:50]:

Oh, that’s, it’s a it’s a new drug development application, essentially. So when a pharma company wants to, you know, Do a clinical study. They have to file an IND with the FDA to essentially initiate that study, let the FDA know, like, hey. This is the molecule that we wanna, like, assess and evaluate. And then from that point on, that molecule is suddenly classified as a drug rather than something like a dietary ingredient or a supplement, regardless of the fact that it’s just a naturally occurring molecule that’s already present in the body. It’s it’s, yeah, it’s not a safety thing. It’s just a regulatory thing.

Nick Urban [00:35:27]:

Gotcha. Okay. Did you say how you guys settled on the different dosages for each of the 4?

Dr. Chris Rhodes [00:35:32]:

No. I didn’t. Great points. So how we settled on the dosages for each of the 4 was essentially through that pilot study that we were talking about. So we assessed All of the different ingredients at 3 different dosages, the low dose, the medium dose, and the high dose, which was constitutively like One x, two x, and three x concentrations. And then we looked at specifically, you know, what was the level of each of the molecules that was required to actually have some kind of functional benefit at the end of the day. And what we found was that the low dosage was Totally sufficient to have all of these great metabolic effects, you know, within hours of taking it, enhanced cardioprotective ability, enhanced anti inflammatory ability, enhanced It’s aoxone ability. So that was how we actually developed the dosage, not through any kind of, like, guesswork, but through Truly doing a full fledged Pharmacyl PK study.

Nick Urban [00:36:29]:

Gotcha. Okay. And you said that the low dose of each of the ones that you tested was sufficient, and you got the benefits just from the low dose. You didn’t you use the medium or high dose of any of them?

Dr. Chris Rhodes [00:36:39]:

Yeah. That’s right. And so you did see, you saw a certain degree of additive benefit. And this especially as you went up to the high dose, there was an even more significant benefit there. So it was a very linear, kind of increase. But one of the things that we wanted to be conscious of was, like, cost and then also biomass. So, like, we didn’t wanna have people take, like, 5 pills a day. We actually like, this was back in the day too when we had to use the spermidine rich wheat germ extracts, which was, like, not super it’s, like, you know, 0.1% actual spermidine.

Dr. Chris Rhodes [00:37:13]:

So we had people taking, like, 20 pills in order to get to, like, the high dose in the actual Luckily, now, you know, we were able to get our hands on purified spermidine, so it’s a lot, you know, less heavy of a lift. But, Yeah. That was that was one of the big things. Then we also didn’t want the product to be, you know, like $250. So that’s, you know, that’s another reason why we went with The the low dose because it was clinically effective, and then, you know, a lot a lot easier on the consumer.

Nick Urban [00:37:45]:

I like that. And also if you’re able to get the same benefits or even greater benefits from taking a high dose, the low dose is usually gonna cause fewer side effects or complications.

Dr. Chris Rhodes [00:37:55]:

Yeah. That’s absolutely true. And what’s interesting is that, you know, that’s that’s how we develop a dosage in the 1st place, but we Then, you know, we’ve been partnering up with, clinical longevity, clinics around the world, to essentially assess Mimio, See how it works best. And one of the things that they’re using it for right now is actually to help wean their clients off of the GLP one agonists like Ozempic and Wegovy because of Mimio’s appetite suppression effects. And what they’ve seen is that, taking 3 Mimio is really where people get the biggest appetite suppression that is very akin to what they experience on Ozempic or Wegovy. So based on that, we’re actually doing a reformulation of the product to enhance the bioactives. So we’re keeping the price the same, But we’re increasing the actual, like, bioactive components by 50%. So what you would currently get in 3 pills, you’re now gonna get in 2 pills, and that’s, you know, just to give our customers a better experience, make sure that we’re providing value to folks.

Dr. Chris Rhodes [00:39:03]:

And, you know, really, that’s that’s the main thing for us. We wanna make sure that the product is effective and actually useful for people’s lives.

Nick Urban [00:39:11]:

Will you break down the GLP one agonist? Because I’ve talked about them or actually, I wrote about them a little bit on the in an article that I wrote, but I haven’t discussed them at all in the podcast, and I have my hesitations against them. For your average person, they can be miracles for people who really Need them, but for your average person looking to get a little more fit and to drop some stubborn body fat, I see a lot of potential Complications and problems. So can you break down what they are and how and why this is such a exciting breakthrough?

Dr. Chris Rhodes [00:39:43]:

Yeah. Absolutely. I mean, the big thing with Ozempic and Wegovy, essentially how they work is they’re what’s called a GLP one agonist. So they are stimulating the same receptors as GLP one that’s naturally produced by your body, a natural hunger hormone. They are simulating the same receptor that GLP one would stimulate. And then through that, They’re enhancing the satiety, reducing cravings, and essentially keeping your metabolic rate high Even when you’re reducing calories. So that’s kind of why Ozempic and Wegovy work so well is because not only are they reducing the amount that you’re eating kind of, like, effortlessly and naturally, but they’re also helping to maintain your metabolic rate. Whereas, you know, in a chlor Restricted environment.

Dr. Chris Rhodes [00:40:32]:

Ordinarily, without the GLP one, you know, stimulation, you would have a very natural decrease in metabolic as your body tries to enhance its metabolic efficiency. The big downside of of Ozempic and Wegovy It’s essentially that, like, number 1, there’s a lot of side effects that are associated with it. Like, very, like, terrible nausea, like, you know, indigestion, gut problems. And then also if you ever come off of it, you kind of almost always categorically, like, regain all the weight Because what happens is the GLP one stimulation basically goes away, and your body was now used to this very high level of stimulation of that receptor. So then when it goes away, you almost get, like, hunger withdrawals Is is kind of how it works. So people become very ravenous. They, like, they go back to their normal eating habits, and then they regain the weight, if not more weight than before. So it becomes, you know, this very treacherous cycle of once you get on it, it’s very hard to get off of it, Which is great for pharma companies, but not great for people who just wanna live their lives without having to pay $1,000 a month to do

Nick Urban [00:41:45]:

And what happens if someone stops taking Mimio and they

Dr. Chris Rhodes [00:41:49]:

Oh, perfect. And that and that’s the great thing. We’re like, that’s why we’re very excited about partnering with these clinics And, like, seeing them use Mimio that way, is because it actually helps people get off of the GLP one agonists, while, you know, continuing to give them the hunger suppression effects, but without any of the negative side effects, you can, like, very easily go off Mimio and not Have that same, you know, style of of withdrawal because it’s not a, like, chemical modulated molecule. Right? It’s just a natural. Your body knows what this is and knows how to utilize it and knows how to break it down, so there’s no there’s no negative adaptation that happens.

Nick Urban [00:42:30]:

Chris, will you speak to why you think it’s important to actually test the different molecules in combination and not just Cherry picked the research of each of these specific compounds in isolation and saying, well, we we’re adding a bunch of them together, therefore, it must be better than each of them individually.

Dr. Chris Rhodes [00:42:48]:

Yeah. That’s a that’s a great point. And you see this kind of all the time, with formulators who yeah. Like, let me give you a Twenty ingredient formulation that, you know, all the individual ingredients have these great clinical backing behind them. But, do they actually work together? I don’t know, and that’s a big problem. And one of the things that the biomimetic approach really solves is that you can identify which molecules actually do work together, which do have synergy. And, like, when you’re not doing that, you can have molecules that are, Like, counter counterproductive to each other. So the the big one that I like to talk about is calcium and magnesium.

Dr. Chris Rhodes [00:43:29]:

Right? So it’s like if you’re pay if you’re taking calcium and magnesium at the same time, it seems like, oh, great. Like, win win. Right? But In reality, the way that your body actually absorbs those 2 molecules is through the same, what’s called a symporter. So the mechanism that you, like, Take in calcium and magnesium, they have to use the same pathway, so they compete with each other. So when you take calcium and magnesium together, You’re not gonna absorb really any of that magnesium because the calcium is gonna outcompete it for the resources to actually get into the cell. And you see this kind of thing happen with bioactives all the time too. You have, you know, 1 bioactive stimulating this pathway and then another bioactive stimulating another pathway that then Cancels out this pathway, so there’s just a lot of cross reactions that can happen. So it’s really important whenever you create a formulation, even though most people don’t Actually, do it.

Dr. Chris Rhodes [00:44:21]:

It’s really important to test the full formulation together and see, okay, these are actually activating complementary pathways And creating effects that are greater than the sum of their parts rather than competing with each other. And that’s was what was really important for us when designing the Mimio formulation is that we weren’t cherry picking molecules, just based on their clinical evidence. We were actually assessing them in the lab, in the clinic To make sure that they all worked together.

Nick Urban [00:44:51]:

Mhmm. Are there any very prominent examples that come to mind in terms of, like, Supplements or specifically longevity supplements that clash and are counterproductive together?

Dr. Chris Rhodes [00:45:01]:

Yeah. That’s a good question. There’s none that specifically Come to mind for me, and I think that a big problem in that like, I can’t say that is because, like, we were talking about a lot of people don’t actually assess their formulations. Right? They put these things together, based off of individual clinical studies from individual molecules, But then never bother to assess their full formulations together and just kind of assume that things are gonna work. Yeah. I I can’t think of a specific interaction between any of the Any of the big longevity ones that would kind of, like, contraindicate each other. Although some of them might be redundant. I think that’s kind of the big thing is that, You know, if you’re going out there and you’re being like, alright.

Dr. Chris Rhodes [00:45:41]:

I’m gonna take, you know, 3 different AMPK activators. Right? Or I’m gonna take Three different Nicotinamide or, like, NAD precursors, like, that’s not really gonna do anything additive for you. And you see that in formulations all Time where you have multiple things that all do the same thing, and they don’t really need to be in there. And what you really want Is, you know, different things that activate different pathways that all of them work together. And that’s the great thing about the biomimetic approach is that that’s exactly what you’re getting at. Because the beauty of it is when you research things that have, you know, gone through Thousands and thousands of years of evolution, like, these molecules that are in Mimio not only evolved to work within the human body, But moreover, they evolved to work together in this larger context of creating these benefits of fasting. So they actually do activate these complementary pathways that kind of unlock even greater benefits than any one of them individually, And that’s what we saw in our actual lifespan analysis as well. So we tested, you know, here’s the lifespan extension, You know, with, 1 MNA, with spermidine, with PEA, with OEA, and then all 4 of them together, And we saw that, yes, while each of the molecules extended lifespan individually, you know, by 5%, 10%, 20%, whatever it was, All of them together extended it by 96%.

Dr. Chris Rhodes [00:47:10]:

So there’s no competition. There’s actually synergy, and that’s the big the big discovery, like, really kind of using nature as a cheat code to, like, finding these great synergistic molecular combinations.

Nick Urban [00:47:22]:

And you said that all of the ingredients within Mimio are found naturally elevated in the blood after 36 hours of fasting?

Dr. Chris Rhodes [00:47:30]:

Yep. That’s right. And even more than that, you don’t find them really elevated in the blood until you get to 36 hours of fasting. So, when we did the when we did the clinical study to do the fasting assessment, we actually assessed 4 different states, the baseline state, which is an overnight fast, so, like, 12 hours of fasting, what people typically experience on a day to day basis From the time they go to bed to the time they wake up. Then we looked at a 2 hour postprandial state. So, like, we had them eat a meal, then 2 hours later, took their plasmas, and this is what we called the fed state. Then they did their 36 hour fast. Then in the 4th time point after the fast, we had them eat a meal, look at the 2 hours after that, And then compare it across all different states.

Dr. Chris Rhodes [00:48:20]:

And these molecules just really did not appear elevated in circulation until 36 hours of Fasting, just like a typical overnight fast, was not enough to get them up there.

Nick Urban [00:48:30]:

Oh, okay. And so these are all coming from diet some form, or are they also coming, like is the body naturally producing them, like mixing and matching different raw materials to create them?

Dr. Chris Rhodes [00:48:40]:

Yeah. So they are all metabolites, Which means that they are in some form or another, like a breakdown product or an intermediary product of, you know, nutrient metabolism. So, like, Spermidine, for example, comes from arginine breakdown. You know, Nicotinamide is a vitamin b three derivative. Of, OEA is a oleic acid derivative. PEA is a palmitic acid derivative. So all of these, you know, those raw components of metabolism that then get, like, broken down through various x, y, and z steps to then become this metabolite inside of your body that has its own specific function and bioactivity.

Nick Urban [00:49:19]:

That’s pretty cool. And I’m imagining that you could also do this if you’re able to find enough participants for a study for, say, a a 4 day fast or a 5 day fast instead of just looking at metabolites after a 36 hour fast, and I wonder if you’d find Different ones there, but then again, the compliance of a 4 day fast is gonna be much harder.

Dr. Chris Rhodes [00:49:37]:

Yeah. And recruiting is also Yeah. Also a lot harder too. But, yeah, I think that that would be really, really interesting, and I think that you would find distinct things between, you know, a 36 hour fast, a 48 hour fast, a 72 hour fast. And that’s something that’s definitely on our radar as continued research to do. You know, just as, you know, even beyond that, just as we ran this Process with fasting, then you can also look at all these other interesting regenerative states of the body like, you know, exercise or meditation or cold exposure therapy and see, you know, what interesting metabolites, what interesting molecules the human body creates that are, you know, signaling through these beneficial pathways and then put those things on demand as well. And that’s kind of The big underlying philosophy behind Mimio, we wanna be the biomimetic human health company and really tease out the mysteries of, you know, How our biology operates in these interesting states and find a way to recreate them.

Nick Urban [00:50:37]:

I was actually gonna mention and ask about those exact things, exercise, mimicry, and then also Heat from such as, like, a sauna or a cold and also, like, meditation. There’s a bunch of really cool, unique states to get into and be fascinating to see if you could, Replicate those benefits and, like, help people get there without usually doing the activity that no one wants Do a very small subset of population actually wants to engage in.

Dr. Chris Rhodes [00:51:02]:

Yeah. Yeah. Exactly. And I mean, like, you know, the the major the major caveat to this is that we don’t wanna be a company that, like, you promotes laziness. Right? Like, I do think that people should still fast. I do think that people should still exercise and meditate and, like, do the cold exposure and things like that. But I think that there is a lot of benefit to be gained by looking at the human body in these more extreme states that people aren’t gonna experience on a day to day basis, It’s like a 36 hour fast. Right? Most people are just never really gonna get there.

Dr. Chris Rhodes [00:51:32]:

So providing the benefits of these fasting metabolites on a day to day, like how it can have these really profound impacts like we saw on the lifespan extension analysis and like we see in the metabolic assessments of, like, really being able to Control a lot of these big, you know, metabolic disease risk factors.

Nick Urban [00:51:50]:

How’d you go about evaluating the safety of these? Because you could Also see how there’s a potential. Like, if you’re gonna be consuming these molecules that wouldn’t naturally be elevated unless you’re fasting, like, Perhaps the reason that they’re not elevated to begin with is, like, a protection mechanism. And if if you go around that protection mechanism, then perhaps you’re you’re venturing into territory that your biology doesn’t wanna venture into.

Dr. Chris Rhodes [00:52:14]:

Yeah. What’s really interesting about that hypothesis, is You you can’t we like, we’ve actually had this conversation a little bit before with, just some other folks. So they were looking at Mimio for, like, Use for stroke patients. And there’s, like, good clinical evidence to show that a lot of the ingredients in Mimio can be very beneficial for, for stroke prevention and then stroke recovery, specifically. But one of the doctors noted that, You know, these things are, like, very highly upregulated, like, you know, after a stroke. Don’t you think that, like, they could be, like, Causing the problem. And I always I always like that argument because it’s like, well, sure. You know, if a building is on fire, you’re probably gonna see a lot of Firemen there.

Dr. Chris Rhodes [00:53:03]:

Right? Like, trying to put on the fire, but the firemen are the ones that are responsible for the fire getting started. And I would say that that’s kind of like a good analogy for Mimio’s ingredients as well is that they are there to help solve the problem. Like, they solve they they resolve stress. They promote recovery. So when, like, these stressors happen, that’s when they kind of show up. So, Like, in terms of how we actually assessed safety. Like, number 1, we did do the dosing and PK study. Number 2, these molecules have, you know, they have their own clinical history over a 100 different studies that are supporting them, and the longest time frame of that Was about a year’s worth of supplementation.

Dr. Chris Rhodes [00:53:45]:

And in that time point, there were no adverse effects ever reported. I don’t think there’s ever than any adverse effects reported with these molecules because, again, they’re already, you know, naturally present inside of your body. Your body inherently knows how to, like, Take them up, process them, utilize them. So there’s there’s just really not a lot of of risk of downside there. And then in terms of, are these things like, you know, should they constantly be upregulated? Again, like, I think that that’s philosophically a very good question, but all I can say is, like, a scientist is the data shows me that them Constantly being present is actually really beneficial, and and has great positive health impacts and lifespan extension effects and not the other way around.

Nick Urban [00:54:33]:

These compounds aren’t like some of the other ones that are recommended to take, say, 5 days on, 2 day off type of approach to them.

Dr. Chris Rhodes [00:54:41]:

Yeah. Exactly. And the nice thing is that, you know, like, some of the other things, you know, that are more of a natural part of your daily metabolism, like, you know, if you get on, Like testosterone replacement therapy, let’s say. Like, yeah, you do you’re gonna have, like, you know, withdrawals that happen from that because you have your certain baseline level of testosterone that’s, like, always gonna be secreted, and then your body gets lazy. It doesn’t want to secret it anymore. And then if you go off the testosterone, then it has to, like, you know, get back up to baseline. Whereas with these molecules, because they’re not typically produced outside of the context of a 36 hour fast, there’s no adaptation that really happens. Right? Like, you wouldn’t experience these molecules unless you were doing 36 hours of fasting.

Dr. Chris Rhodes [00:55:23]:

So they, you know, you you can’t, like, get adapted to them or interrupt your normal functioning because of it.

Nick Urban [00:55:30]:

Okay. Yeah. That makes a lot of sense. We have I have a couple more questions for you before we start to wrap This one up. And the first one is if there are any other components to your personal, like, longevity, routine, or protocol.

Dr. Chris Rhodes [00:55:43]:

Yeah. So the the 2 ones that are major for me are definitely taking Mimio, and then also doing, the fasting. Those are those are kind of my 2 big things. I would say the other one is just, like, daily strength training, weight training exercises. One of the best things that you can do for longevity is to actually, like, add muscle mass. That’s one of the best, like indicators of longevity, especially after the age of, like, 55 or 65. You can basically tell, like, who’s going to live for another, like, 30 years versus who’s going to live for another 10 years just based on how much muscle you have going into that 65 age mark. I also think that you need to do that in a very responsible way.

Dr. Chris Rhodes [00:56:29]:

You know, like, most of the time, what we See, ironically, from a longevity point of view is folks that do, like, really hardcore, really high intensity, training, Like Olympic athletes or, you know, like big bodybuilders, wrestlers, things like that, they actually don’t have all that great longevity because, You know, when you’re pushing yourself to those extremes over and over and over again, especially, in more of the high intensity versions versus, you know, more of the, like, marathon endurance style things, then that’s like really exhausted for your immune system, which can kind of, you know, deteriorate over time and give you more Chronic inflammation, inflamaging. So I think that doing strength training, but, like, low impact strength Training with, like, a lot of guardrails in place so that you don’t injure yourself, that’s kind of the way to go.

Nick Urban [00:57:18]:

I’m glad you brought that up because that’s one that’s not often discussed when it comes to longevity, and it’s so pivotal in terms of, like, healthy longevity when you need it most, which is when you’re aging in your later years and you become resistant to putting on muscle, that’s when you actually need it so you don’t get frail, which is, like, one of the leading causes of later life conditions.

Dr. Chris Rhodes [00:57:41]:

Yeah. Sarcopenia and just like falls in general, they’re they’re they’re big killers. And then, of course, you know, there’s the underlying effects and also helping to prevent cardiovascular disease, help prevent, like, these metabolic problems. I think that that’s something that’s really key as well. I always think it’s funny going back to Ozempic and Wegovy. People Kind of. Or, like, I can’t believe that it’s impacting all these different areas of society just through, like, a metabolic health Product. Right? But it’s like, yeah.

Dr. Chris Rhodes [00:58:11]:

You know, people are eating less food, so it’s affecting, like, you know, the food system. People are having less disease, so it’s affecting the pharma system. Right? And, like, everybody’s super surprised at this, but I think it’s really funny because, like, well, of course. Right? Like, metabolic health and longevity are just Inherently tied together. Like, if you take care of your metabolic health, that’s gonna be one of the primary, determinants of how well and how Quickly you age and your quality of life, especially as you get into into later life. So really, like, focusing on Metabolic health and its impacts can help control so many things, including the actual rate of aging, that that’s it’s kind of just the the most important thing that I can possibly tell people and just really focus on metabolic health.

Nick Urban [00:59:00]:

Yeah. And to briefly summarize what metabolic health is, it’s essentially the ability to efficiently and effectively convert your Things you intake, the food, the water into energy to power your entire body. Yep. That’s great. Simple way to put it. Yeah. Okay, Chris. If people wanna connect with you, they wanna try Mimio pick up a order, How do they go about that?

Dr. Chris Rhodes [00:59:25]:

Yeah. You can check us out at mimiohealth.com, mimiohealth.com. You can find our clinical studies there. You can learn more about the brand there. And if you want to give us a try, we’re also gonna give, Nick The urban fifteen code, and that’ll give him, and his folks listening 15% off their first, onetime purchase of Mimio or 15% off their 1st 3 months when you sign up for a subscription.

Nick Urban [00:59:57]:

Thanks for setting that up. If there was a worldwide burning of the books and all knowledge was lost, but you got to save the works of 3 teachers, Who would you choose and why?

Dr. Chris Rhodes [01:00:07]:

I would default to, like, entertaining things. I would I would be like, okay. Cool. I wanna like, I wanna continue to read, like, The works of Tina Fey and, like, Amy Poehler and, like, and, like, Donald Glover. Like, the philosophy stuff doesn’t, like, get to me quite as much. I would be like, I want the world to have laughter if all knowledge is destroyed and to have, like, a good sense of, you know, like, not taking itself too seriously, preaching more of, like, empathy and compassion towards others and just being like the one of my favorite things that Amy Poehler wrote was, You know, like, good for you, not for me. Right? And just kind of, like, coming to that acceptance of, like, you know, it’s also like a very scientific thing that, like, what works some people, it might not work for everybody, right, and just kind of like live and live and let live. So that would be my big my big thing.

Nick Urban [01:00:55]:

Yeah. Okay. And what is one thing the Mimio Health tribe does not know about you?

Dr. Chris Rhodes [01:01:00]:

One thing the Mimio Health tribe probably does not know about me is that In addition to being, you know, the CEO, founder of Mimio, and also a PhD in nutritional biochemistry, I’m also a internationally award winning meadmaker. Okay. Really? Yeah. So mead, for those that do not know, is honey wine. And one of the reasons why I got really into mead was While I was at UC Davis, it has one of the best, mead making programs in the country because there’s a really large honey and pollination center at UC Davis That’s run by Amina Harris, who is just a phenomenal person. She also has, like, a honey distribution company. And so UC Davis puts on all of these really interesting, like, mead making, honey tasting courses that, like, student that are available to students, but also, like, professional mead makers as well. So that’s kind of where I, like, got the exposure to it, like, got my teeth cut, and kind of, like, learned all of the all of the techniques around mead making and all the interesting different, like, nuances of honey varietals, which are a lot like grape varietals in that, You know, depending on where the bees are foraging and where their pollen is coming from, it totally changes the taste of the honey.

Dr. Chris Rhodes [01:02:15]:

So you can get something like Clover honey. Right? That’s like cinnamon all day long. Or you can something like meadowfoam, which is like cotton candy and marshmallows, and then you have, like, chestnut honey that’s like Leather and, like, molasses and, like, bitter. And it’s it’s really, really crazy. Just like, I I know so much more about honey than I ever thought I thought I would and that most people don’t. And then that’s, yeah, that’s kind of what got me what got me into it in the 1st place, and I got really good at meat making. So that’s that’s the that’s the thing that I do, and I enjoy Responsibly alongside you.

Nick Urban [01:02:49]:

Yes. That is I can’t say I ever had a internationally acclaimed meat maker on the show, so that is a cool story.

Dr. Chris Rhodes [01:02:56]:

Fun fact, check a runny.

Nick Urban [01:02:58]:

Absolutely. Well, Chris, how would you like to wrap this one up today? Any takeaways you wanna leave listeners with?

Dr. Chris Rhodes [01:03:04]:

Yeah. I mean, like, just to just to kinda recap what we said, you know, I’m doctor Chris Rhodes. I’m the CEO of Mimio Health where we are making, you know, The world’s 1st biomimetic supplements, and our first one is a fasting mimetic based on years of clinical research to give you the cellular health and benefits of fasting, like, without actually having to fast. And if you wanna give us a try, you can check it out at mimiohealth dotcom, m I m I o health dot com, and use the code urban fifteen to get 15% off your Q1 or 15% off your 1st 3 months of subscription. Egyptian.

Nick Urban [01:03:40]:

Awesome. Thank you for that, and I’m gonna look forward to trying your other BioMimetic products when they also come out, such as your exercise mimetic or your meditation mimetic and all that. So I look forward to staying in touch and keeping up to date.

Dr. Chris Rhodes [01:03:56]:

Yeah. It’s gonna be great.

Nick Urban [01:03:58]:

Alright, Chris. It was a pleasure hosting you on the show today.

Dr. Chris Rhodes [01:04:01]:

Alright. Thanks a lot, Nick. Appreciate it.

Nick Urban [01:04:04]:

I hope that this has been helpful for If you enjoyed it, subscribe and hit the thumbs up. I love knowing who’s in the 1% committed to reaching their full potential. Comment 1% below so that I know who you are. For all the resources and links, meet me on my website at mind body peak .com. I appreciate you and look forward to connecting with you.

Connect with Dr. Chris Rhodes @ Mimio Health

This Podcast Is Brought to You By

Nick Urban is a Biohacker, Data Scientist, Athlete, Founder of Outliyr, and the Host of the Mind Body Peak Performance Podcast. He is a Certified CHEK Practitioner, a Personal Trainer, and a Performance Health Coach. Nick is driven by curiosity which has led him to study ancient medical systems (Ayurveda, Traditional Chinese Medicine, Hermetic Principles, German New Medicine, etc), and modern science.

Nick Urban

Music by Luke Hall

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