The anti-aging/longevity industry changes fast so I brought on Ryan Smith, a biological aging expert, for a second round. In this one, we discuss some of the most promising emerging trends.
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About Ryan Smith
Ryan Smith attended Transylvania University and graduated with a degree in Biochemistry. After finishing all the educational curriculum and passing USMLE Step 1 he decided to leave and open up a pharmacy in the United States that focused on peptide synthesis and formulations for pharmaceutical preparations. That pharmacy, Tailor Made Compounding, became the 4th fastest growing company in healthcare in the US. During that time Ryan invested in several businesses in functional medicine space. Ryan exited Tailor Made in late 2020. Since then, Ryan has opened many businesses including TruDiagnostic, a company focusing on methylation array-based diagnostics for life extension and preventive healthcare. TruDiagnostic is a CLIA certified lab and health data company focused on serving integrative and functional medicine providers in the United States. TruDiagnostic has a commitment to research with over 30 approved clinical research studies investigating the epigenetic methylation changes of a variety of longevity and health interventions. Since Tru Diagnostic’s inception, they have created one of the largest private epigenetic health databases in the world with over 13,000 patients tested and continues to lead the space in epigenetic methylation interpretation and diagnostic prediction
Top things you’ll learn from Ryan
- How Ryan evaluates longevity protocols
- Summary of biological aging from episode 47
- What is epigenetics and its relation to biological aging
- What is aging and how it is measured
- What is hazard ratio
- Why TruDiagnostic focused on epigenetic methylation instead of other forms of biological age testing
- Difference of 1st, 2nd and 3rd generation biological aging clocks
- What is imprintome and the human imprint project
- Study of mice exposed to BPA and/or vitamins
- Mark Woolen’s book “It Didn’t Start with You” and inherited trauma
- Study done by Trudiagnostic and North Carolina State to decode the human imprintome
- How to avoid passing trauma down through generations
- How exposures change imprintome regions
- Measuring your biological age via epigenetics is safe
- Importance of twins in epigenetic research
- What’s new in longevity and biological age testing
- What is the Human Genome Project
- What are multiomic clocks
- Impact of immune system on epigenetic age
- How to change our biological age and overall bodily performance
- Basic things to implement to slow biological age
- Nick Urban’s approach to improving overall performance
- Health and stress management effects on longevity
- Highest impact areas of focus to make your health and performance easier
- Ryan’s perspective on popular anti-aging therapies
- Methylene Blue
- Antioxidants such as melatonin, glutathione, superoxide dismutase, and chlorophyll
- Senolytic agents
- Pterostilbene
- Spermidine
- Astaxanthin
- Vitamin C
- Blood sugar regulators, metformin, berberine, the rock lotus, certain vitamins and minerals
- Natural sunlight
- Red light therapy
- Filtering water
- Green spaces and other essential lifestyle habits
- Ryan’s stance on NAD precursors, NMN, MIB-626
- Small molecules Ryan uses for performance
- Nootropics and supplements for cognitive performance
- Semax
- Dihexa
- Tesofensine
Resources mentioned
- Test: TruDiagnostic Tests (save 12% with code URBAN)
- Previous episode: How to reverse biological age and the science of epigenetic testing
- Book: It Didn’t Start With You
- Teacher: Jonathan Mill
- Skincare: One Skin Skincare
Connect with Ryan @TruDiagnostic
This Podcast Is Brought to You By
Nick Urban is a Biohacker, Data Scientist, Athlete, Founder of Outliyr, and the Host of the Mind Body Peak Performance Podcast. He is a Certified CHEK Practitioner, a Personal Trainer, and a Performance Health Coach. Nick is driven by curiosity which has led him to study ancient medical systems (Ayurveda, Traditional Chinese Medicine, Hermetic Principles, German New Medicine, etc), and modern science.
Music by Luke Hall
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