The Ancient Japanese Longevity Scrolls & Spermidine

  |   EP46   |   68 mins.

Leslie Kenny

Spermidine may be the hottest anti-aging compound of the last decade, but is it possible that ancient Japanese longevity scrolls alluded to it over a century ago? What other wisdom did these scrolls contain?

Thanks to our guest this week, these nearly-forgotten secrets live on.

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Episode highlights

"Eat bitter foods for a sweet life" Share on XWhen we lose the body's innate ability to regenerate itself, we've lost half the battle Share on X

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About Leslie Kenny

Oxford Healthspan was founded by Leslie Kenny, a Southern Californian entrepreneur and graduate of both Berkeley and Harvard, whose life was turned upside down when she was diagnosed with lupus and rheumatoid arthritis in her 30s. When her doctors told her lupus had a life expectancy of five years and that RA could only be managed, not cured, she set out to optimize her health as best she could with safe, natural solutions. She went back to school at the Institute for Integrative Nutrition in NYC, became a Bulletproof coach under health pioneer Dave Asprey, and took on health coaching clients worldwide.

At the same time, she began helping life science academics at European universities, including Oxford (where she lives), to raise money for their discoveries. At a meeting with one such scientist, she learned about a natural compound called spermidine, abundant in nattō, a traditional Japanese dish that she had grown up with. Spermidine was showing great promise in supporting health as we age. The science was compelling – one scientist even called it “an anti-aging vitamin” in a published scientific journal – and it was safe. Still, because it was natural, food-derived, and not a drug that would bring in more money, no one was interested in promoting it. Leslie immediately wanted her octogenarian mother back home in California to take it – especially since nattō is very hard to come by (it’s pretty smelly, for one thing!) Unfortunately, spermidine wasn’t available in the US (or really even known there). Spotting this unmet need, she decided to bring it to the US herself.

Today, at age 56, Leslie is living proof that we can get better with age, so long as we take responsibility for our health and meet our doctors halfway.

Top things you’ll learn from Leslie Kenny

  • Healthspan is about living to old age but with the most vibrant years
  • Oxford Longevity Project is about empowering individuals with tools and knowledge to inhibit aging
  • The problem with classifying aging as a disease
  • What is Spermidine and might it be regulated/banned by the FDA?
    • There to protect sperm against the oxidative event of fertilization
    • Also found in human breastmilk
    • Essential for creating and ensuring life
    • Infants have the highest concentration of spermidine
    • Naturally occurring in wheat germ, soybeans, sprouts, peas, mushrooms, fermented foods, natto
  • Natto linked to longevity and health benefits, primarily by triggering autophagy
  • 9 pathways of aging
    • Explains how much of aging?
  • We know there are different speeds of biological aging
  • Popular longevity supplements & compounds
    • Spermidine, NMN, fisetin, molecular hydrogen, pterostilbene, astaxanthin, etc
  • What is autophagy and why it’s important
    • Rubicon protein inhibits spermidine and thus autophagy
  • Benefits of spermidine
    • Immunity
    • Cognition
    • Heart health
    • Hair, skin, nail health
  • Keys to buying organ meats
  • Ishin Ho for longevity & sexual intimacy
  • How to tell if Spermidine products are legit
    • FDA registration means its been internal tested and passed quality controls (CoA)
    • Minimal fillers (like talc)
    • Ingredients that get your body to manufacture spermidine (like a prebiotic)
    • What it’s derived from
    • Less than 6mg per day, according to European Food Safety Association (EFSA)
    • Wheat germ-based products are best because they contain spermine, spermidine, and putrescine
  • Beginner’s guide to photobiomodulation (light therapy)
  • The fascinating science of blood flow restriction training (and KAATSU in particular)

Resources mentioned

  • Resource: PubMed
  • Supplement: C8 MCT Oil
  • Supplement: Collagen Protein Powder
  • Gear: KAATSU training system (code URBAN saves 5%)
  • Works: Ishin Ho
  • Teacher: Yoshinori Ohsumi
  • Teacher: William Shakespeare

Connect with Leslie

This podcast is brought to you by

Nick Urban is a Biohacker, Data Scientist, Athlete, Founder of Outliyr, and the Host of the Mind Body Peak Performance Podcast. He is a Certified CHEK Practitioner, a Personal Trainer, and a Performance Health Coach. Nick is driven by curiosity which has led him to study ancient medical systems (Ayurveda, Traditional Chinese Medicine, Hermetic Principles, German New Medicine, etc), and modern science.

Nick Urban

Music by Luke Hall

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